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Surrogate Endpoints: CONSORT and SPIRIT Extensions
Journal of Dental ResearchF. Schwendicke, N.S. Jakubovics
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A meta-analysis of GFR slope as a surrogate endpoint for kidney failure
Nature Medicine, 2023Lesley A Inker +2 more
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GFR slope as a surrogate endpoint for CKD progression in clinical trials
Current opinion in nephrology and hypertension, 2020Purpose of review There is a paucity of therapies for chronic kidney disease (CKD), in part because of the slow nature of the disease which poses challenges in selection of endpoints in randomized controlled trials (RCT). There is increasing evidence for
L. Inker, Juhi Chaudhari
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Evaluating surrogate endpoints
Controlled Clinical Trials, 2002The validation of surrogate endpoints has been studied by Prentice, who presented a definition as well as a set of criteria that are equivalent if the surrogate and true endpoints are binary. Freedman et al. supplemented these criteria with the so-called proportion explained.
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Expert Review of Clinical Pharmacology
Introduction Single-arm trials (SATs) and surrogate endpoints were adopted as pivotal evidence for accelerated approval of anticancer drugs for more than 30 years.
Yafang Huang, Jinqiu Yuan
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Introduction Single-arm trials (SATs) and surrogate endpoints were adopted as pivotal evidence for accelerated approval of anticancer drugs for more than 30 years.
Yafang Huang, Jinqiu Yuan
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Challenge of Surrogate Endpoints
Southern Medical Journal, 2012Surrogate endpoints are biomarkers that are intended to substitute for clinical endpoints. They have been used to find novel therapeutic targets, improve the statistical power and shorten the duration of clinical trials, and control the cost of conducting research studies.
James L, Furgerson +2 more
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True endpoint reduction by surrogate endpoints
Communications in Statistics - Simulation and Computation, 2016ABSTRACTThe use of surrogate endpoint, which is becoming widely popular now a days, was introduced in medical research to reduce the time of experiment required for the approval of a drug. Through cost cutting and time saving, the surrogate endpoints can bring profit to the medicine producers. We obtain the expression for the reduction of true samples,
Buddhananda Banerjee, Atanu Biswas
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2023
In Chapter 3, I utilize publicly available datasets of gene expression and DNA methylation in sarcomas to interrogate PRC2-dependent mechanisms of epigenetic crosstalk. I have shown that loss of PRC2 correlates with a global hypermethylation profile, tumor microenvironment changes, and patient outcome.
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In Chapter 3, I utilize publicly available datasets of gene expression and DNA methylation in sarcomas to interrogate PRC2-dependent mechanisms of epigenetic crosstalk. I have shown that loss of PRC2 correlates with a global hypermethylation profile, tumor microenvironment changes, and patient outcome.
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Surrogate Endpoints in Suicide Research
Suicide and Life-Threatening Behavior, 2010Surrogate endpoints frequently substitute for rare outcomes in research. The ability to learn about completed suicides by investigating more readily available and proximate outcomes, such as suicide attempts, has obvious appeal. However, concerns with surrogates from the statistical science perspective exist, and mounting evidence from psychometric ...
Hal S, Wortzel +4 more
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