Results 41 to 50 of about 82,696 (289)

Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE

BMJ Open, 2022
Introduction Randomised controlled trials (RCTs) may use surrogate endpoints as substitutes and predictors of patient-relevant/participant-relevant final outcomes (eg, survival, health-related quality of life).
Martin Offringa, Nancy J Butcher, Derek Stewart, An-Wen Chan, Oriana Ciani, Philippa Davies, Christopher J Weir, Mario Ouwens, Dalia Dawoud, Sylwia Bujkiewicz, Anthony Muchai Manyara   +10 more
doaj   +1 more source

Thromboprophylaxis in atrial fibrillation and association with cognitive decline: systematic review [PDF]

, 2016
Objective:Atrial Fibrillation (AF) is associated with dementia. If AF-related cognitive decline is driven by cerebral embolic events, thromboprophylaxis may impact on this.
Lane, Deirdre A., Moffitt, Peter, O'Connell, Janice, Park, Helen, Quinn, Terence J.   +4 more
core   +2 more sources

Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis

Intensive Care Medicine Experimental, 2018
Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), and Mouse ...
Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw   +7 more
doaj   +1 more source

Evidence regarding clinical use of microvolt T-wave alternans [Accuracy of microvolt T-wave alternans testing] [PDF]

, 2011
Background: Microvolt T-wave alternans (MTWA) testing in many studies has proven to be a highly accurate predictor of ventricular tachyarrhythmic events (VTEs) in patients with risk factors for sudden cardiac death (SCD) but without a prior history of ...
Cohen, Richard J., Hohnloser, Stefan H., Ikeda, Takanori   +2 more
core  

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors

Current Controlled Trials in Cardiovascular Medicine, 2005
Background Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT) of the carotid artery ...
Morgan Timothy, Terry James G, O'Leary Daniel H, Espeland Mark A, Evans Greg, Mudra Harald   +5 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Surrogate endpoints for overall survival in digestive oncology trials: which candidates? A questionnaires survey among clinicians and methodologists

BMC Cancer, 2010
Background Overall survival (OS) is the gold standard for the demonstration of a clinical benefit in cancer trials. Replacement of OS by a surrogate endpoint allows to reduce trial duration.
Bonnetain Franck, Bedenne Laurent, Methy Nicolas   +2 more
doaj   +1 more source

Qualitative Evaluation of Associations by the Transitivity of the Association Signs

, 2014
We say that the signs of association measures among three variables {X, Y, Z} are transitive if a positive association measure between the variable X and the intermediate variable Y and further a positive association measure between Y and the endpoint ...
Ding, Peng, Geng, Zhi, Jiang, Zhichao
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source