Results 51 to 60 of about 510,312 (368)

Is blood pressure reduction a valid surrogate endpoint for stroke prevention? an analysis incorporating a systematic review of randomised controlled trials, a by-trial weighted errors-in-variables regression, the surrogate threshold effect (STE) and the biomarker-surrogacy (BioSurrogate) evaluation schema (BSES)

BMC Medical Research Methodology, 2012
Background Blood pressure is considered to be a leading example of a valid surrogate endpoint. The aims of this study were to (i) formally evaluate systolic and diastolic blood pressure reduction as a surrogate endpoint for stroke prevention and (ii ...
Lassere Marissa N, Johnson Kent R, Schiff Michal, Rees David   +3 more
doaj   +1 more source

Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials

BMC Cancer, 2020
We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer.
Run-Cong Nie, Xue-bin Zou, S. Yuan, Ying-Bo Chen, Shi Chen, Yong-ming Chen, Guoming Chen, Xiao-Jiang Chen, Tian-Qi Luo, Shuman Li, Jin-Ling Duan, Yun Wang, Yuan-Fang Li   +12 more
semanticscholar   +1 more source

What every ICU clinician needs to know about the cardiovascular effects caused by abdominal hypertension [PDF]

, 2015
The effects of increased intra-abdominal pressure (IAP) on cardiovascular function are well recognized and include a combined negative effect on preload, afterload and contractility.
De Keulenaer, Bart L, De Waele, Jan, Malbrain, Manu LNG   +2 more
core   +1 more source

CSF early fungicidal activity as a surrogate endpoint for cryptococcal meningitis survival in clinical trials.

Clinical Infectious Diseases, 2020
BACKGROUND In cryptococcal meningitis phase two clinical trials, early fungicidal activity (EFA) of Cryptococcus clearance from cerebrospinal fluid (CSF) is used as a surrogate endpoint for all-cause mortality.
M. Pullen, K. H. Hullsiek, Joshua Rhein, A. Musubire, L. Tugume, E. Nuwagira, M. Abassi, K. Ssebambulidde, Edward Mpoza, Ruben Kiggundu, A. Akampurira, Henry W. Nabeta, C. Schutz, Emily E. Evans, R. Rajasingham, C. Skipper, K. Pastick, Darlisha A Williams, B. Morawski, A. Bangdiwala, G. Meintjes, C. Muzoora, D. Meya, D. Boulware   +23 more
semanticscholar   +1 more source

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics [PDF]

, 2018
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types.
A. Abeshouse, A. Ally, A. Antenucci, A. Arnaout, A. Berchuck, A. Bergeron, A. Bossler, A. Boussioutas, A. Breggia, A. Burnette, A. Chen, A. Clipca, A. Davis, A. De Rienzo, A. De Rose, A. Fehrenbach, A. Gillis, A. Gimenez-Roqueplo, A. Gopalan, A. Haddad, A. Hartmann, A. Jimeno, A. Kastl, A. Kendler, A. Kibel, A. Korkut, A. Longatto-Filho, A. Luna, A. Malykh, A. Mariamidze, A. Mes-Masson, A. Noss, A. Ochoa, A. Perin, A. Piché, A. Pickens, A. Rao, A. Sankarankuty, A. Secord, A. Sepulveda, A. Shabunin, A. Sharp, A. Sood, A. Spillane, A. Tam, A. Tischler, A. Tsao, A. Unterberg, A. Vicha, A. von Deimling, A.C. Berger, A.C. de Carvalho, A.D. Cherniack, A.D. Cherniack, A.E. Sloan, A.G. Robertson, A.H. Bryce, A.H. Perou, A.J. Kovatich, A.J. Kovatich, A.J. Lazar, A.J. Lazar, A.J. Mungall, A.K. Godwin, A.L. Carvalho, A.L. Guillermo, A.M. Angulo Gonzalez, A.M. Hegde, A.P. Hoyle, A.R. Metwalli, A.V. Lee, B. Bernard, B. Campos, B. Czerniak, B. Deyarmin, B. Drake, B. Esmaeli, B. Hermes, B. Hernandez, B. Kohl, B. Kumar, B. Pollo, B. Rabeno, B. Robinson, B. Singh, B. Tê, B. Van Tine, B. Wullich, B.D. Phu, B.E. Gross, B.M. Broom, B.P. O’, B.S. Taylor, B.Y. Karlan, C. Adebamowo, C. Andry, C. Behrens, C. Benz, C. Bifulco, C. Bradford, C. Brewer, C. Calatozzolo, C. Carter, C. Chen, C. Cibulskis, C. Fan, C. Farver, C. Feltmate, C. Goparaju, C. Guo, C. Herold-Mende, C. Hovens, C. Jungk, C. Kandoth, C. Larson, C. Logothetis, C. Mcpherson, C. Mirsaidi, C. Moran, C. Morrison, C. Moser, C. Sander, C. Scapulatempo-Neto, C. Schilero, C. Shelton, C. Shipman, C. Stoehr, C. Yau, C.A. Miller, C.C. Benz, C.C. Fronick, C.D. Jones, C.D. Shriver, C.D. Shriver, C.D. Vocke, C.H. Hagedorn, C.J. Creighton, C.K. Wong, C.M. Cebulla, C.M. Hutter, C.M. Perou, C.N. Landen, C.P. Raut, C.S. Shelley, C.W. Seder, D. Alvaro, D. Aziz, D. Beer, D. Bell, D. Bigner, D. Brooks, D. Chakravarty, D. Chesla, D. Crain, D. Cramer, D. Hoon, D. Huntsman, D. Lee, D. Mallery, D. Morton, D. Murawa, D. Muzny, D. Nagorney, D. O’, D. Raymond, D. Rice, D. Schadendorf, D. Tan, D. Tcaciuc, D. Tirapelli, D. Voet, D.A. Levine, D.A. Levine, D.A. Wheeler, D.I. Heiman, D.J. Brat, D.J. Van Den Berg, D.J. Weisenberger, D.M. Rassl, D.M. Shin, D.M. Wolf, D.N. Hayes, D.O. Vidal, D.T. Maglinte, E. Baudin, E. Campo, E. Castle, E. Chuah, E. Curley, E. Gaudio, E. Giné, E. Kebebew, E. Korpershoek, E. Lipp, E. Reznik, E. Shinbro, E. Swisher, E. Thompson, E. Zmuda, E.C. Zwarthoff, E.G. Van Meir, E.L. Appelbaum, E.M. Godwin, E.M. Mora Pinero, E.R. Duffy, E.R. Mardis, F. Beuschlein, F. Brimo, F. Carey, F. Cheng, F. Dimeco, F. Facciolo, F. Giuliante, F. Khuri, F. Meric-Bernstam, F. Moiseenko, F. Que, F. Saad, F. Sanchez-Vega, F. Valdivieso, F. Williams, F. Zhao, G. Barnett, G. Bubley, G. Carlos, G. Carpino, G. Finocchiaro, G. Getz, G. Gorincioi, G. Grazi, G. Long, G. Manikhas, G. Mann, G. Mckercher, G. Petersen, G. Saksena, G. Sauter, G. Setdikova, G. Sica, G. Thomas, G. Wolf, G.B. Mills, G.F. Gao, H. Al-Ahmadie, H. Colman, H. Dinh, H. Doddapaneni, H. Fan, H. Gabra, H. Gavin, H. Hai, H. Hai, H. Hibshoosh, H. Huland, H. Jianhong, H. Juhl, H. Kakavand, H. Liang, H. Noushmehr, H. Pass, H. Sekhon, H. Shen, H. Stoop, H. Taubert, H. Thai, H. Timmers, H. Yang, H. Zaren, H. Zhang, H. Zhang, H. Zhang, H.C.S. Silveira, H.G. Rosenthal, H.J. Sofia, H.K. Schmidt, I. Alexopoulou, I. Caraman, I. Chemencedji, I. de Bruijn, I. Felau, I. Forgie, I. Shmulevich, I. Stancul, I. Wistuba, I. Yang, J. Armenia, J. Bartlett, J. Bennett, J. Bondaruk, J. Bowen, J. Carlotti, J. Catto, J. Chabot, J. Cheville, J. Cho, J. Creaney, J. Dipersio, J. Drummond, J. Eckman, J. Engel, J. Eschbacher, J. Fujimoto, J. Fulop, J. Galbraith, J. Gao, J. Gardner, J. Gershenwald, J. Harr, J. Henderson, J. Hess, J. Hilty, J. Houck, J. Kim, J. Kocher, J. Lang, J. Liu, J. Liu, J. Luketich, J. Marks, J. Martin, J. Melamed, J. Miller, J. Moyer, J. Myers, J. Parfitt, J. Park, J. Paulauskis, J. Phillips, J. Powers, J. Roach, J. Santibanez, J. Shih, J. Simko, J. Slotta-Huspenina, J. Smith, J. Stretch, J. Thompson, J. Waldmann, J. Walker, J. Wang, J. Wang, J. Wilmott, J. Zhang, J. Zhenlin, J.(. Zhang, J.A. Ajani, J.A. Borgia, J.A. Copland, J.A. Demchok, J.A. Hooke, J.A. Martignetti, J.B. Elder, J.C. Zenklusen, J.D. Yang, J.E. Schein, J.H. Fregnani, J.I. Lee, J.J. Olson, J.L. Fantacone-Campbell, J.M. Chan, J.M. Gastier-Foster, J.M. Stuart, J.N. Weinstein, J.S. Barnholtz-Sloan, J.S. Dos Santos, J.S. Parker, J.T. Auman, J.V. Simons, K. Agnew, K. Ahn, K. Becker, K. Birsoy, K. Chang, K. Chung, K. Covington, K. Delman, K. Devine, K. Evason, K. Janssen, K. Junker, K. Kasaian, K. Kopp, K. Lau, K. Lee, K. Leinonen, K. Magliocca, K. Moore, K. Moxley, K. Mungall, K. Pacak, K. Rai, K. Roggin, K. Senecal, K. Shannon, K. Shimmel, K. Smith-McCune, K. Smolenski, K. Tse, K. Tucker, K.A. Hoadley, K.A. Hoadley, K.C. Sexton, K.E. van Kessel, K.J. Kang, K.M. Fong, K.M. Leraas, L. Cope, L. Cuppini, L. Danilova, L. Desjardins, L. Ding, L. Haydu, L. Jacobus, L. Jun, L. Konnor, L. Kvecher, L. Lacombe, L. Landrum, L. Lewis, L. Lolla, L. Looijenga, L. Mattei, L. Omberg, L. Omberg, L. Peterson, L. Ramondetta, L. Roberts, L. Rozek, L. Scarpace, L. Schoenfield, L. Wang, L. Wei, L. Wise, L. Xuan, L. Yang, L. Yiling, L. Zhang, L.A. Donehower, L.A. Fulton, L.A. Zach, L.E. Mose, L.M. Poisson, L.S. Schmidt, M. Albert, M. Aymerich, M. Bailey, M. Balasundaram, M. Behera, M. Bellair, M. Birrer, M. Borad, M. Carney, M. Cernat, M. Couce, M. Deqin, M. Dinkin, M. Dubina, M. Farnell, M. Fassnacht, M. Feldman, M. Gerken, M. Goodman, M. Graefen, M. Iacocca, M. Ittmann, M. Kasapi, M. Kendrick, M. Knudson, M. Ladanyi, M. Latour, M. Mannelli, M. Marino, M. Mayo, M. Mcgraw, M. Meyerson, M. Milhem, M. Miller, M. Moncrieff, M. Morgan, M. Muto, M. Nelson, M. Peto, M. Pirtac, M. Pool, M. Prados, M. Prince, M. Quinn, M. Quintero-Aguilo, M. Rivera, M. Ryan, M. Schiffman, M. Sherman, M. Sheth, M. Stanton, M. Stern, M. Synott, M. Tavobilov, M. Torbenson, M. Wang, M. Wiznerowicz, M. Yussanne, M.A. Marra, M.A. Rubin, M.C. Bragazzi, M.D. Mclellan, M.D. Wilkerson, M.G. Cordes, M.G. Nissan, M.G. Soloway, M.H. Abdel-Rahman, M.H. Kucherlapati, M.J. Liptay, M.L. Anderson, M.L. Ferguson, M.S. Bootwalla, M.S. Lawrence, M.S. Noble, N. Botnariuc, N. Chambwe, N. Corcoran, N. Dhalla, N. Gehlenborg, N. Giama, N. Girard, N. Hayward, N. Horowitz, N. Kwok-Shing, N. Schultz, N. Thiessen, N. Van Bang, N. Wentzensen, N.A. Pennell, N.C. Ramirez, N.D. Aredes, N.L. Lehman, N.P. Hung, N.V. Tien, O. Bathe, O. Mariani, O. Olabode, O. Paklina, O. Potapova, O. Voronina, P. Anur, P. Disaia, P. Drwiega, P. Glenn, P. Hansen, P. Hersey, P. Lin, P. Lohavanichbutr, P. Nair, P. Nguyen, P. Sipahimalani, P. Spellman, P. Swanson, P. Tamboli, P. Tennstedt, P. Troncoso, P. Wakely, P. Westervelt, P. Yena, P.A. Mieczkowski, P.A. Pinto, P.D. Castro, P.H. Lai, P.R. Carroll, P.R. Dottino, P.T. Hanh, P.W. Laird, Q. Sun, Q.T. Ostrom, R. Akbani, R. Berkowitz, R. Beroukhim, R. Bowlby, R. Bowman, R. Broaddus, R. Bueno, R. Carlsen, R. de Krijger, R. Dhanasekaran, R. Dhir, R. Duell, R. Ghossein, R. Glenn, R. Govindan, R. Holt, R. Kefford, R. Kemp, R. Korst, R. Kramer, R. Kundra, R. Lechan, R. Madan, R. Mandt, R. Mannel, R. Mclendon, R. Merola, R. Naresh, R. Penny, R. Pilarski, R. Postier, R. Saw, R. Scolyer, R. Sheridan, R. Sigmund, R. Simon, R. Singh, R. Smallridge, R. Steele, R. Stoehr, R. Tamakawa, R. Tarnuzzer, R. Thorp, R. Warnick, R. Worrell, R. Zuna, R.A. Gibbs, R.A. Moore, R.C. Rintoul, R.H. Thompson, R.J. Mural, R.K. Kelley, R.K. Wilson, R.M. Reis, R.S. Fulton, R.S. Kanchi, R.S. Kucherlapati, S. Balu, S. Baylin, S. Bell, S. Chevalier, S. Chudamani, S. Cottingham, S. Cuzzubbo, S. Doruc, S. Force, S. Frazer, S. Gilbert, S. Heath, S. Kalkanis, S. Kendall, S. Lee, S. Ling, S. Maithel, S. Mccall, S. Meier, S. Meng, S. Morris, S. Mura, S. Porten, S. Ramalingam, S. Reynolds, S. Roman-Roman, S. Sadeghi, S. Sifri, S. Signoretti, S. Singer, S. Somiari, S. Stepa, S. Tao, S. Vandenberg, S. Wach, S.B. Gabriel, S.E. Schumacher, S.J. Caesar-Johnson, S.J.M. Jones, S.L. Asa, S.M. Phillips, S.M. Staugaitis, S.N. Adebamowo, S.O. Sumer, S.R. Jefferys, T. Akeredolu, T. Bocklage, T. Bodenheimer, T. Broudy, T. Carey, T. Costello, T. Defreitas, T. Flotte, T. Giordano, T. Hinoue, T. Knijnenburg, T. Knutson, T. Ley, T. Lichtenberg, T. Mikkelsen, T. Naska, T. Owonikoko, T. Patel, T. Pihl, T. Schlomm, T. Shelton, T. Skelly, T. Smyrk, T. Thompson, T. Wang, T. Wong, T. Zelinka, T.A. Chan, T.M. Lichtenberg, U. Veluvolu, V. Cardinale, V. Chandan, V. Dhankani, V. Jakrot, V. Korchina, V. Lyadov, V. Reuter, V. Thorsson, V. Thorsson, W. Barrett, W. Eijckenboom, W. Hale, W. Kycler, W. Liu, W. Oosterhuis, W. Urba, W. Ye, W. Zhang, W. Zhou, W.E. Grizzle, W.G. Richards, W.J. Edenfield, W.K. Chatila, W.K. Rathmell, W.M. Linehan, X. Liu, X. Liu, X. Sastre, Y. Han, Y. Liu, Y. Shi, Y. Sun, Y. Tang, Y. Wan, Y. Wolinsky, Z. Wang, Z.J. Heins   +740 more
core   +2 more sources

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Prognostic and therapeutic implications of measurable residual disease in acute myeloid leukemia

Journal of Hematology & Oncology, 2021
Quantification of measurable residual disease (MRD) provides critical prognostic information in acute myeloid leukemia (AML). A variety of platforms exist for MRD detection, varying in their sensitivity and applicability to individual patients.
Marisa J. L. Aitken, Farhad Ravandi, Keyur P. Patel, Nicholas J. Short   +3 more
doaj   +1 more source

Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process. [PDF]

, 2015
A number of meta-analytical methods have been proposed that aim to evaluate surrogate endpoints. Bivariate meta-analytical methods can be used to predict the treatment effect for the final outcome from the treatment effect estimate measured on the ...
Abrams, KR, Bujkiewicz, S, Riley, RD, Thompson, JR   +3 more
core   +2 more sources

The perils of surrogate endpoints [PDF]

European Heart Journal, 2015
Our goals in medicine are (i) to improve the quality of patients' lives, (ii) help them to live longer, and (iii) to do so at a reasonable cost. These are our true endpoints: health status, survival, and cost. It is thus entirely consistent with this point of view that these are the fundamental concepts that can be united in a formal cost–utility ...
Weintraub, William S, Lüscher, Thomas F, Pocock, Stuart   +2 more
openaire   +4 more sources

Biomarkers and surrogate endpoints [PDF]

British Journal of Clinical Pharmacology, 2005
When David Beckham leaves the field towards the end of a match, the man who replaces him is a surrogate. and although I suspect that many footballers, if asked, would say that Surrogate is a town in Yorkshire, the word actually comes from the Latin word subrogare, to substitute.
openaire   +3 more sources