Results 81 to 90 of about 510,312 (368)

Interferon β-1a in relapsing multiple sclerosis: four-year extension of the European IFNβ-1a Dose-C omparison Study [PDF]

, 2004
Background: Multiple sclerosis (MS) is a chronic disease requiring long-term monitoring of treatment. Objective: To assess the four-year clinical efficacy of intramuscular (IM) IFNb-1a in patients with relapsing MS from the European IFNb-1a Dose-C ...
Achiti, J., Arbizu, T., Arnulf, I., Aubertin, P., Bamborschke, P., Belliard, S., Berger, E., Blanc, S., Brassat, D., Brochet, B., Cahagne, V., Casado, A., Cesaro, P., Chan, A., Clanet, M., Confavreux, C., Dalecky, A., Damier, P., de Keyser, Jacques, de Marco, A., Defer, G., Degos, F., Dengler, R., Dose, A., Edan, G., Engles, A., Fernandez, O., Flachenecker, A., Gayou, A., Gelderblom, H., Grunwald, F., Grupe, A., Hartung, H.P., Heesen, C., Heidenreich, F., Heinzlef, O., Hohlfeld, R., Kappos, L., Kassim, N., Koehler, A., Koerner, A., Kristoferitsch, W., Kunze, K., Kyriallis, K., Lau, G., Lecanuet, P., Lindert, A., Liu, A., Lubetzki, C., Luenemann, J., Lyon-Caen, O., Magnier, C., Martin, A, Martinez-Yelamos, A., Matzke, A., Maurer, A., Mekies, C., Menck, A., Montalban, X., Moulin, A., Nolden, A., Nos, A., Pantzaris, A., Papacostas, S., Pelletier, J., Petereit, H., Pez, D., Piette, A., Riche, G., Rieckmann, P., Romero, F., Rouanet, M., Rouant, F., Roullet, E., Rumbach, L., Sailer, 27449, Schaeffer, S., Schlederer, A., Schrieber, A., Seeldrayers, P., Senard, A., Stankoff, B., Steiner, A., Stingle, A., Storch-Hagenlocher, A., Storch-Hagenlocher, B., Suchet, L., Tamayo, J.A., Tamman, D., Thalamas, C., Vermersch, P., Vogt-Schaden, A., Vuilleman, C., Weilbach, A., Weiler, C., Windhagen, A., Zorgdrager, A., Zschenderlein, R., Zwanniken, G.   +98 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The Impasse on Overall Survival in Oncology Reimbursement Decision-Making: How Can We Resolve This?

Cancer Management and Research, 2021
Michael Patrick Lux, 1 Oriana Ciani, 2 William CN Dunlop, 3 Andrea Ferris, 4 Michael Friedlander 5 1Department of Gynecology and Obstetrics, Frauenklinik St. Louise Paderborn, St. Josefs-Krankenhaus Salzkotten, Frauen- und Kinderklinik St.
Lux MP, Ciani O, Dunlop WCN, Ferris A, Friedlander M   +4 more
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Transcatheter interatrial shunt device for the treatment of heart failure with preserved ejection fraction (REDUCE LAP-HF I [Reduce Elevated Left Atrial Pressure in Patients With Heart Failure]): A phase 2, randomized, sham-controlled trial [PDF]

, 2018
Background -In non-randomized, open-label studies, a transcatheter interatrial shunt device (IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure (PCWP), less symptoms, and greater quality of life and exercise capacity in ...
Basuray, Anupam, Burkhoff, Daniel, Fail, Peter S., Feldman, Ted, Forde-McLean, Rhondalyn, Hummel, Scott L., Kahwash, Rami, Kaye, David M., Lilly, Scott, Litwin, Sheldon, Massaro, Joseph M., Mauri, Laura, Nielsen, Christopher D., Penicka, Martin, Petrie, Mark C., Ricciardi, Mark J., Shah, Sanjiv J., van der Harst, Pim   +17 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Surrogate Endpoints in Pivotal Clinical Trials for Drug Approval in Japan Compared to the United States

Clinical and Translational Science
Regulatory guidance documents exist on surrogate endpoints in the United States. In Japan, there are no established rules or guidance regarding the use of surrogate endpoints, and various aspects remain unclear.
Yuko Yamamoto, Harumi Kosaka, Hanami Nojiri, Hideki Maeda   +3 more
doaj   +1 more source

Evaluating Causal Effect Predictiveness of Candidate Surrogate Endpoints [PDF]

, 2006
Most methods for evaluating surrogate endpoints measure validity in terms of net effects (i.e., treatment effects adjusted for the biomarker measured after randomization).
Gilbert, Peter B., Hudgens, Michael
core   +1 more source

Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG) [PDF]

, 2012
The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man.
BABILONI, CLAUDIO, Boeijinga PH, Brunovsky M, Drinkenburg WH, Ffytche DH, Freeman J, Hegerl U, Hirata K, IPEG Pharmaco EEG Guidelines C.o.m.m.i.t.t.e.e. Collaborators, Jobert M, Kinoshita T, Knott VJ, Lopes Da Silva FH, Matousek M, Mucci A, Nottage JF, Olbrich S, Prichep LS, Ruigt GS, Saletu B, Stancak A, Strik WK, van Gerven JM, Wilson FJ, Wise RG   +24 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source