Results 121 to 130 of about 79,600 (335)

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2017
Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials.
Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm   +3 more
doaj   +1 more source

Reducing the Probability of False Positive Research Findings by Pre-Publication Validation - Experience with a Large Multiple Sclerosis Database [PDF]

, 2007
*Objective* We have assessed the utility of a pre-publication validation policy in reducing the probability of publishing false positive research findings.
George G. Ebers, Katja K. Ickstadt, Martin M. Daumer, Moritz M. Heinz, Siegfried S. Schach, Ulrike U. Held   +5 more
core   +1 more source

Left ventricular mass as a surrogate endpoint in the treatment of hypertension [PDF]

, 1997
R DEVEREUX
openalex   +1 more source

Is myocardial infarction a surrogate endpoint for all-cause mortality? A trial-level meta-analysis of 144 randomized controlled trials enrolling 1.2 million patients from 1972–2020 [PDF]

, 2021
Katie O’Fee, Elena Deych, Oriana Ciani, David Brown   +3 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Surrogate endpoints: a key concept in clinical epidemiology

Journal of Clinical Epidemiology
Surrogate endpoints are biomarkers or intermediate outcomes that are used as substitutes for clinical outcomes of interest, often to expedite research or decision-making. In contrast, patient-important (or patient-centered) outcomes are health outcomes that are of direct relevance and importance to patients themselves; clinical trials may have measured
Robin Christensen, Oriana Ciani, Anthony M. Manyara, Rod S. Taylor   +3 more
openaire   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Surrogate to predict overall survival in patients with BRAF V600E-mutant colorectal cancer treated with BRAF inhibitor combinations

ESMO Gastrointestinal Oncology
Background: The BRAF V600E mutation, found in up to 12% of patients with metastatic colorectal cancer, is associated with aggressive disease and poor response to standard chemotherapy.
J. Ros, V. Navarro, G. Villacampa, I. Baraibar, F. Salvà, M. Rodriguez, C. Vaghi, A. Garcia, A. Alcaraz, J. Tabernero, E. Élez, R. Dienstmann   +11 more
doaj   +1 more source

Decision letter for "Validation of the Surrogate Threshold Effect for Change in BMD as a Surrogate Endpoint for Fracture Outcomes: the FNIH‐ASBMR SABRE Project"

, 2021

openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source