Results 131 to 140 of about 277,103 (274)

Handling missing within-study correlations in the evaluation of surrogate endpoints. [PDF]

Stat Med, 2023
Collier W, Haaland B, Inker L, Greene T.
europepmc   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Statistical validation of surrogate endpoints: problems and proposals

, 2000
Prentice proposed a definition of surrogate endpoints and operational criteria for their validation. Freedman supplemented these criteria with the proportion explained, which is supposed to represent the proportion of the treatment effect upon the true ...
Molenberghs, Geert, Buyse, Marc E., Renard, Didier, Geys, Helena, Burzykowski, Tomasz   +4 more
core   +1 more source

The Portability of Surrogate Endpoints. [PDF]

J Clin Pharmacol
Bair H.
europepmc   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Bias in Meta-Analytic Modeling of Surrogate Endpoints in Cancer Screening Trials. [PDF]

Stat Med
Long JP, Roy A, Irajizad E, Do KA, Shen Y.   +4 more
europepmc   +1 more source

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) is a minimally invasive therapy for drug‐resistant focal epilepsy. However, the relationship between specific seizure‐onset patterns (SOPs), particularly low‐voltage fast activity (LVFA), and postoperative scalp EEG normalization remains inadequately ...
Yi‐qing Yang, Rui Zhang, Haiyan Ma, Lu Yang, Xuefeng Qu, Qiqi Chen, Yan Zhang   +6 more
wiley   +1 more source

A framework to evaluate surrogate endpoints at the trial level: analysis in colorectal cancer. [PDF]

J Natl Cancer Inst
Chia BJ, Allegra C, Krishnamurthi S, Lieu C, Loree JM, Shi Q.   +5 more
europepmc   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Surrogate endpoints in cost-effectiveness analysis for use in health technology assessment - a qualitative analysis. [PDF]

Int J Technol Assess Health Care
Flight L, Salih F, Collins SD, Aung P, Coory M, Ollendorf DA, Richardson M, Garrett Z.   +7 more
europepmc   +1 more source