Results 121 to 130 of about 43,465 (252)

A call for better reporting of trials using surrogate primary endpoints

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Anthony Muchai Manyara, Oriana Ciani, Rod S. Taylor   +2 more
doaj   +1 more source

Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process. [PDF]

Stat Med, 2022
Bujkiewicz S.
europepmc   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Association Between Surrogate Endpoints and Clinical Outcomes in Immunoglobulin A Nephropathy: A Systematic Literature Review. [PDF]

Adv Ther
Lorenzi M, Ali SN, Cadarette S, Ebohon S, Diaby V, Mathur M, Fernandes AW.   +6 more
europepmc   +1 more source

A proposal to analyze the progression of non-dialytic chronic kidney disease by surrogate endpoints: introducing parametric survival models. [PDF]

Front Med (Lausanne), 2023
Erohildes Ferreira R, Sanders-Pinheiro H, Basile Colugnati FA.   +2 more
europepmc   +1 more source

In Situ Micromechanical Study of Bimodal γ′–γ″ Precipitate Assemblies in Ni–Cr–Al–Nb Superalloy

Advanced Engineering Materials, EarlyView.
A Ni–Cr–Al–Nb superalloy with a bimodal γ′–γ″ precipitate distribution is developed. Composite precipitate assemblies form through heterogeneous nucleation, effectively impeding dislocation motion. Micropillar compression reveals high strength at room and elevated temperatures, governed by precipitate shearing, with coupled faulting mechanisms ...
Ujjval Bansal, Tae‐Hyeok Kang, Pyuck‐Pa Choi, Subin Lee, Christoph Kirchlechner   +4 more
wiley   +1 more source

Significance of biomarkers and surrogate endpoints in preclinical and clinical trials [PDF]

Vojnosanitetski Pregled, 2007
Ilić Katarina, Kuntić Vesna
doaj   +1 more source

Surrogate endpoints for survival in KEYNOTE-585: neoadjuvant/adjuvant pembrolizumab plus chemotherapy versus placebo plus chemotherapy for gastric or gastroesophageal junction adenocarcinoma. [PDF]

ESMO Open
Shitara K, Bang YJ, Wyrwicz LS, Rha SY, Oshima T, Pietrantonio F, Park YK, Lonardi S, Yañez P, Yen CJ, Metges JP, Garrido M, Moehler M, Pelles-Avraham S, Yong WP, Spallanzani A, Jensen E, Krishnan R, Shih CS, Al-Batran SE.   +19 more
europepmc   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source