Results 191 to 200 of about 22,296,575 (338)

Comparison of parallel infill sampling criteria based on Kriging surrogate model. [PDF]

Sci Rep, 2022
Chen C, Liu J, Xu P.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

MULTI-OBJECTIVE OPTIMIZATION DESIGN OF MOTOR TRAIN UNIT TRUCK FRAME BASED ON HYBRID ADDITION KRIGING SURROGATE MODEL

Jixie qiangdu
To enhance the computational efficiency of structural lightweight design for complex structures, a structural lightweight design method based on the Kriging surrogate model is proposed.
WANG Weiqi, SONG Yubo, WANG Ying
doaj  

A GRU-KAN Surrogate Model with Genetic Algorithm Uniform Sampling for Active Magnetic Bearings-Rotor Critical Speed Prediction. [PDF]

Sensors (Basel)
Cui J, Li J, Cai F, Zhao Z, Liu Y.
europepmc   +1 more source

The Monocytic Cell Line THP-1 as a Validated and Robust Surrogate Model for Human Dendritic Cells. [PDF]

Int J Mol Sci, 2023
Hölken JM, Teusch N.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares. [PDF]

Metabolomics
Tatara Y, Yamamoto H, Terai K, Matsuta R, Kasai S, Tamada Y, Mikami T, Murashita K, Itoh K.   +8 more
europepmc   +1 more source

Uncertainty quantification in cerebral circulation simulations focusing on the collateral flow: Surrogate model approach with machine learning. [PDF]

PLoS Comput Biol, 2022
Yuhn C, Oshima M, Chen Y, Hayakawa M, Yamada S.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Speed up Multi-Scale Force-Field Parameter Optimization by Substituting Molecular Dynamics Calculations with a Machine Learning Surrogate Model. [PDF]

Chemphyschem
Strickstrock R, Hagg A, Reith D, Kirschner KN.   +3 more
europepmc   +1 more source