Results 61 to 70 of about 557,108 (293)

Optimization of a piezoelectric fan using fluid-structure interaction simulation [PDF]

, 2010
In this paper, the heat transfer from a single heat fin to the air flow in the wake of a piezoelectric fan (piezofan) is optimised. Both the heat fin and the piezofan are positioned in a channel, which has a significant influence on the flow field.
Annerel, Sebastiaan, Debrouwere, Brecht, Degroote, Joris, Vierendeels, Jan   +3 more
core   +2 more sources

Large scale variable fidelity surrogate modeling [PDF]

Annals of Mathematics and Artificial Intelligence, 2017
Engineers widely use Gaussian process regression framework to construct surrogate models aimed to replace computationally expensive physical models while exploring design space. Thanks to Gaussian process properties we can use both samples generated by a high fidelity function (an expensive and accurate representation of a physical phenomenon) and a ...
A. Zaytsev, E. Burnaev
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Surrogate Model Based on Artificial Neural Networks for Wave Propagation in Uncertain Media

IEEE Access, 2020
Soil materials can exhibit strongly dispersive properties in the operating frequency range of a physical system, and the uncertain parameters of the dispersive materials introduce uncertainties in the simulation result of propagating waves.
Xi Cheng, Zhi-Yong Zhang, Wei Shao
doaj   +1 more source

Evolutionary model type selection for global surrogate modeling [PDF]

, 2009
Due to the scale and computational complexity of currently used simulation codes, global surrogate (metamodels) models have become indispensable tools for exploring and understanding the design space.
De Turck, Filip, Dhaene, Tom, Gorissen, Dirk   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Convergence of Weak-SINDy Surrogate Models

SIAM Journal on Applied Dynamical Systems
In this paper, we give an in-depth error analysis for surrogate models generated by a variant of the Sparse Identification of Nonlinear Dynamics (SINDy) method. We start with an overview of a variety of non-linear system identification techniques, namely, SINDy, weak-SINDy, and the occupation kernel method.
Benjamin P. Russo, M. Paul Laiu
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Surrogate Models and Ensemble Strategies for Expensive Evolutionary Optimization: An Industrial Case Study

IEEE Access
Expensive optimization problems are characterized by the significant amount of time and resources needed to determine the quality of potential solutions.
Mario Garza-Fabre, Nicolas Cortes-Garcia, Hiram Galeana-Zapien, Ricardo Landa   +3 more
doaj   +1 more source