Results 71 to 80 of about 557,108 (293)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Determination of Bond Wire Failure Probabilities in Microelectronic Packages
, 2016 This work deals with the computation of industry-relevant bond wire failure probabilities in microelectronic packages. Under operating conditions, a package is subject to Joule heating that can lead to electrothermally induced failures.
Casper, Thorben +2 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
AI-Driven Surrogate Model for Room Ventilation
FluidsThe control of ventilation systems is often performed by automatic algorithms which often do not consider the future evolution of the system in its control politics. Digital twins allow system forecasting for a more sophisticated control.
Jaume Luis-Gómez +7 more
doaj +1 more source
Decomposition-Assisted Computational Technique Based on Surrogate Modeling for Real-Time Simulations
Complexity, 2017 The development of complex simulation systems is extremely costly as it requires high computational capability and expensive hardware. As cost is one of the main issues in developing simulation components, achieving real-time simulation is challenging ...
Nariman Fouladinejad +3 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Online learning supported surrogate-based flowsheet model maintenance
Digital Chemical EngineeringSurrogate-based flowsheet model calibration is a critical extension of using flowsheet models in Digital Twin (DT) systems. However, maintaining accurate surrogates over time is increasingly challenging, especially when models are deployed in real-time ...
Balázs Palotai +3 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
An adaptive sampling method for global sensitivity analysis based on least-squares support vector regression [PDF]
, 2018 In the field of engineering, surrogate models are commonly used for approximating the behavior of a physical phenomenon in order to reduce the computational costs.
Bourinet, Jean-Marc +2 more
core
A surrogate function for one-dimensional phylogenetic likelihoods
, 2017 Phylogenetics has seen an steady increase in substitution model complexity, which requires increasing amounts of computational power to compute likelihoods.
Brian C Claywell +4 more
core +1 more source