Results 71 to 80 of about 186,324 (294)

Selecting the Best Quantity and Variety of Surrogates for an Ensemble Model

Mathematics, 2020
Surrogate modeling techniques are widely used to replace the computationally expensive black-box functions in engineering. As a combination of individual surrogate models, an ensemble of surrogates is preferred due to its strong robustness.
Pengcheng Ye, Guang Pan
doaj   +1 more source

Polynomial Response Surface Approximations for the Multidisciplinary Design Optimization of a High Speed Civil Transport [PDF]

, 2001
Surrogate functions have become an important tool in multidisciplinary design optimization to deal with noisy functions, high computational cost, and the practical difficulty of integrating legacy disciplinary computer codes.
Grossman, B., Hosder, S., Kim, H., Mason, W.H., Watson, L.T.   +4 more
core   +1 more source

Metamodel-based importance sampling for the simulation of rare events

, 2011
In the field of structural reliability, the Monte-Carlo estimator is considered as the reference probability estimator. However, it is still untractable for real engineering cases since it requires a high number of runs of the model.
Deheeger, F., Dubourg, V., Sudret, B.
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Hybrid-Surrogate-Calibration-Assisted Multi-Fidelity Modeling Approach and Its Application in Strength Prediction for Underwater Gliders

Journal of Marine Science and Engineering
Multi-fidelity surrogate-based methods play an important role in modern engineering design applications, aiming to improve model accuracy while reducing computational cost.
Chengshan Li, Yufan Cao, Xiaoyi An, Da Lyu, Junxiao Liu   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Surfaces of coastal biogenic structures: exploiting advanced digital design and fabrication strategies for the manufacturing of oyster reef and mussel bed surrogates

Frontiers in Marine Science
Coastal biogenic structures, formed by ecosystem engineering species, often feature rough surfaces characterized by intricate topographies and highly three-dimensional reliefs.
Jan Hitzegrad, Leon Brohmann, Friedrich Herding, Kai Pfennings, Sven Jonischkies, Elisa Scharnbeck, Jeldrik Mainka, Inka Mai, Inka Mai, Christian Windt, Harald Kloft, Achim Wehrmann, Dirk Lowke, Dirk Lowke, Nils Goseberg, Nils Goseberg   +15 more
doaj   +1 more source

ooDACE toolbox: a flexible object-oriented Kriging implementation [PDF]

, 2014
When analyzing data from computationally expensive simulation codes, surrogate modeling methods are firmly established as facilitators for design space exploration, sensitivity analysis, visualization and optimization.
Couckuyt, Ivo, Demeester, Piet, Dhaene, Tom   +2 more
core