Results 91 to 100 of about 22,195,649 (288)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Point-Wise Full-Field Physics Neural Mapping Framework via Boundary Geometry Constrained for Large Thermoplastic Deformation

Algorithms
Computation modeling for large thermoplastic deformation of plastic solids is critical for industrial applications like non-invasive assessment of engineering components.
Jue Wang, Xinyi Xu, Changxin Ye, Wei Huangfu   +3 more
doaj   +1 more source

Approximated models for aerodynamic coefficients estimation in a multidisciplinary design environment [PDF]

, 2011
In this paper variable fidelity analyses are investigated. Moreover different kind of approximations to be used in a wide multidisciplinary design environment for aircraft design are built.
Maggiore, Paolo, Mainini, Laura, Tosetti, Marco   +2 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Reduced chemistry for butanol isomers at engine-relevant conditions

, 2017
Butanol has received significant research attention as a second-generation biofuel in the past few years. In the present study, skeletal mechanisms for four butanol isomers were generated from two widely accepted, well-validated detailed chemical kinetic
Brady, Kyle B., Hui, Xin, Niemeyer, Kyle E., Sung, Chih-Jen   +3 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Full Domain Analysis in Fluid Dynamics

Machine Learning and Knowledge Extraction
Novel techniques in evolutionary optimization, simulation, and machine learning enable a broad analysis of domains like fluid dynamics, in which computation is expensive and flow behavior is complex.
Alexander Hagg, Adam Gaier, Dominik Wilde, Alexander Asteroth, Holger Foysi, Dirk Reith   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A DNN-Based Surrogate Constitutive Equation for Geometrically Exact Thin-Walled Rod Members

Computation
Kinematically exact rod models were a major breakthrough to evaluate complex frame structures undergoing large displacements and the associated buckling modes.
Marcos Pires Kassab, Eduardo de Morais Barreto Campello, Adnan Ibrahimbegovic   +2 more
doaj   +1 more source

Evolutionary model type selection for global surrogate modeling [PDF]

, 2009
Due to the scale and computational complexity of currently used simulation codes, global surrogate (metamodels) models have become indispensable tools for exploring and understanding the design space.
De Turck, Filip, Dhaene, Tom, Gorissen, Dirk   +2 more
core   +1 more source