Results 31 to 40 of about 121,917 (257)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Changes to Irradiation Conditions of VVER-1000 Surveillance Specimens Resulting from Fuel Assemblies with Greater Fuel Height [PDF]

EPJ Web of Conferences, 2016
The goal of the work was to obtain experimental data on the influence of newtype fuel assemblies with higher fuel rods on the irradiation conditions of surveillance specimens installed on the baffe of VVER-1000. For this purpose, two surveillance sets with container assemblies of the same design irradiated in reactors with different fuel assemblies in ...
Panferov Pavel, Kochkin Viacheslav, Erak Dmitry, Makhotin Denis, Reshetnikov Alexandr, Timofeev Andrey   +5 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Detection and typing of vancomycin-resistance genes of enterococci from clinical and nosocomial surveillance specimens by multiplex PCR

Epidemiology and Infection, 2001
Ninety-three clinical isolates of vancomycin-resistant enterococci (VRE) collected from nine hospitals in Taiwan were examined for the presence of vanA, vanB, vanC1, or vanC2/vanC3 genes by a multiplex PCR. Forty-seven of these VRE isolates were vanA positive, 1 contained both vanC1 and vanA, 40 harboured vanB, 2 were vanC1, and 3 were identified to be
J J, Lu, C L, Perng, T S, Chiueh, S Y, Lee, C H, Chen, F Y, Chang, C C, Wang, W M, Chi   +7 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Real-Time RT-PCR Allelic Discrimination Assay for Detection of N501Y Mutation in the Spike Protein of SARS-CoV-2 Associated with B.1.1.7 Variant of Concern

Microbiology Spectrum, 2022
The N501Y amino acid mutation caused by a single point substitution A23063T in the spike gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is possessed by three variants of concern (VOCs), B.1.1.7, B.1.351, and P.1.
Mariana Abdulnoor, AliReza Eshaghi, Stephen J. Perusini, George Broukhanski, Antoine Corbeil, Kirby Cronin, Nahuel Fittipaldi, Jessica D. Forbes, Jennifer L. Guthrie, Julianne V. Kus, Ye Li, Anna Majury, Gustavo V. Mallo, Tony Mazzulli, Roberto G. Melano, Romy Olsha, Ashleigh Sullivan, Vanessa Tran, Samir N. Patel, Vanessa G. Allen, Jonathan B. Gubbay   +20 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Environmental Surveillance of Polio and Non-Polio Enterovi¬ruses in Sistan and Balouchestan Province [PDF]

Iranian Journal of Public Health, 2008
Background: Enteroviruses can easily circulate in the population through sewage and they are suitable indicators for environ­mental surveillance. On the other hand, in some countries there are evidences of silent circulation of viruses in sew­age ...
S Hamed Khodaei, M Kargar , H Tabatabaei , M Sarijlou , R Nategh   +4 more
doaj   +1 more source

Surveillance for Soil-Transmitted Helminths in High-Risk County, Mississippi, USA

Emerging Infectious Diseases, 2023
Recent reports of hookworm infection in Alabama, USA, has prompted surveillance in Mississippi, given the states’ similar environmental conditions. We collected stool specimens from 277 children in Rankin County, Mississippi. Kato–Katz microscopic smear,
Richard S. Bradbury, Lora Martin, Lacy Malloch, Maygan Martin, John M. Williams, Kayla Patterson, Cameron Sanders, Gurbaksh Singh, Irene Arguello, Eduardo Rodriguez, Paul Byers, Lisa Haynie, Yvonne Qvarnstrom, Charlotte V. Hobbs   +13 more
doaj   +1 more source