Results 41 to 50 of about 121,917 (257)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Improving the specimen referral system in Ghana: findings from a landscape assessment

Frontiers in Public Health
IntroductionGhana's specimen referral system (SRS) is driven by vertical surveillance programs and outbreak response events; the lack of integration limits public health disease surveillance capacity.
Christopher Nkrumah, Paa Kobina Forson, Bernard Nkrumah, Richard Owusu, Mohammed Aminu Andrew Musah, Doreenda Enyonam Ahiataku, Gifty Boateng, Pearl Nanka-Bruce, Franklin Asiedu-Bekoe, Horlali Yao Gudjinu, William Addo Mills-Pappoe, John T. Ayivase, Ignatius Nchor Awinibuno, Danielle T. Barradas   +13 more
doaj   +1 more source

Incidence and etiology of infectious diarrhea from a facility-based surveillance system in Guatemala, 2008–2012

BMC Public Health, 2019
Background Diarrhea is a major cause of morbidity and mortality, yet incidence and etiology data are limited. We conducted laboratory-based diarrhea surveillance in Guatemala.
Wences Arvelo, Aron J. Hall, Olga Henao, Beatriz Lopez, Chris Bernart, Juan C. Moir, Lissette Reyes, Susan P. Montgomery, Oliver Morgan, Alejandra Estevez, Michele B. Parsons, Maria R. Lopez, Gerry Gomez, Jan Vinje, Nicole Gregoricus, Umesh Parashar, Eric D. Mintz, John McCracken, Joe P. Bryan, Kim A. Lindblade   +19 more
doaj   +1 more source

HIV drug resistance surveillance using pooled pyrosequencing. [PDF]

PLoS ONE, 2010
BACKGROUND: Surveillance for HIV transmitted drug resistance (TDR) is performed using HIV genotype results from individual specimens. Pyrosequencing, through its massive parallel sequencing ability, can analyze large numbers of specimens simultaneously ...
Hezhao Ji, Nathalie Massé, Shaun Tyler, Ben Liang, Yang Li, Harriet Merks, Morag Graham, Paul Sandstrom, James Brooks   +8 more
doaj   +1 more source

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Intelligent Sky Guardians (InSkyGuard): An Aerial Robotic Swarm for Autonomous Detection and Entrapment of Rogue Multirotors

Advanced Robotics Research, EarlyView.
Intelligent Sky Guardians (InSkyGuard) is introduced as a four‐drone swarm that autonomously detects, tracks, and safely captures rogue drones using a coordinated net system. Computer vision and leader–follower control architecture enable synchronized enclosure, while integrated failsafes enhance system reliability. Validated through closed‐environment
Joshua Hastings, Levanya Dewanarayana, Iline Shaju, Haider Al‐Wizni, Sampson Marquis, Weicheng Huang, Pooya Sareh   +6 more
wiley   +1 more source

Enhanced rabies surveillance in roadkill specimens by real-time RT-PCR.

PLoS Neglected Tropical Diseases
Roadkill specimens are an important source of samples for enhanced rabies surveillance (ERS) in areas where other methods of sample collection may not be practical.
Crystal M Gigante, Claire Hartloge, Rene Edgar Condori, Jordona D Kirby, Lauren Hovis, Kathleen M Nelson, Ryan Wallace, Yu Li, Richard B Chipman   +8 more
doaj   +1 more source

Excluding polio in areas of inadequate surveillance in the final stages of eradication in China

Bulletin of the World Health Organization
In 1996, China adopted a virological classification of acute flaccid paralysis (AFP) cases for its surveillance system. Only AFP cases with wild poliovirus in stool specimens are confirmed as polio.
E.J. Hoekstra, Chai Feng, Wang Xiao-jun, Zhang Xing-lu, Yu Jing-jin, J. Bilous   +5 more
doaj   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source