Results 51 to 60 of about 121,917 (257)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Possibility of a life-time extension for wwer-1000 reactor pressure vessels beyond the design period

Trudy Odesskogo Politehničeskogo Universiteta, 2020
At present a life-time extension for WWER-1000 reactor pressure vessels is an actual issue in Ukraine. For a decision about the life-time extension it is needed to assess mechanical properties and the critical brittleness temperature TK for the RPV ...
Микола Геннадійович Голяк, Володимир Миколайович Ревка, Людмила Іванівна Чирко, Олександр Вікторович Тригубенко, Юрій Віталійович Чайковський   +4 more
doaj   +3 more sources

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Calculational determination of some irradiation condition parameters of surveillance specimens of WWER-1000 reactor pressure vessel

Nuclear Physics and Atomic Energy, 2000
The shortcomings of dosimetry part of surveillance specimen (SS) program that is realizing on Ukrainian NPPs at present are presented. Structure and functioning principles of the program package MCSS, intended for calculation of functionals of neutron flux which influence on SS in WWER-1000 reactor are described.
O.V. Grytsenko, V.N. Bukanov, O.G. Vasylyeva, V.L. Dyemokhin, O.V. Nedyelin   +4 more
openaire   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Detection of polioviruses and non-polio enteroviruses by acute flaccid paralysis and environmental surveillances in Sistan and Balouchestan Province

Iranian South Medical Journal, 2006
Background: In some countries, though wild poliovirus isolation from clinical specimens has not been done, evidences of silent circulation of wild virus in sewage system have been reported. On the other hand, based on WHO recommendations, if there is any
Saeideh alsadat Razavi, Seyed Hamed KHodaee, Mohammad Kargar, Mahboobeh Sarijloo, hamideh Tabatabaee, Rakhshandeh Nategh   +5 more
doaj  

Pooling Upper Respiratory Specimens for Rapid Mass Screening of COVID-19 by Real-Time RT-PCR

Emerging Infectious Diseases, 2020
To validate the specimen-pooling strategy for real-time reverse transcription PCR detection of severe acute respiratory syndrome coronavirus 2, we generated different pools including positive specimens, reflecting the distribution of cycle threshold ...
So Yeon Kim, Jaehyeon Lee, Heungsup Sung, Hyukmin Lee, Myung Guk Han, Cheon Kwon Yoo, Sang Won Lee, Ki Ho Hong   +7 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Clostridioides difficile clinical diagnostic test methods and results are associated with recovery of C. difficile by stool culture

Microbiology Spectrum
Accurate molecular epidemiology relies on recovering Clostridioides difficile from clinical specimens and is essential for informing public health responses, characterizing strains that cause disease, and tracking strain prevalence.
Andrew M. Skinner, Alice Y. Guh, Laurica A. Petrella, Susan Sambol, Adam Cheknis, Stuart Johnson, Christopher A. Czaja, Helen Johnston, Elizabeth Basiliere, Robin A. Dhonau, Lauren Korhonen, Ashley L. Paulick, Matthew H. Samore, Michelle Adamczyk, Amy S. Gargis, Dale N. Gerding   +15 more
doaj   +1 more source