Results 71 to 80 of about 1,413,891 (296)

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 40 2002

, 2002
Welcome to the first influenza surveillance report of the 2002/2003 influenza season. This is the third year of influenza surveillance using computerised sentinel general practices in Ireland. The National Disease Surveillance Centre (NDSC) is working in
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 40

, 2001
This is the first weekly influenza surveillance report of the 2001/2002 influenza season. This report is produced by the National Disease Surveillance Centre, in collaboration with the Virus Reference Laboratory, the Irish College of General ...
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Interim results of the reactor pressure vessel materials evaluation within the framework of the implemented Advanced Surveillance Specimen Programme

Ubiquity Proceedings, 2018
The reactor pressure vessel (RPV) is the most critical component of every nuclear power plant (NPP) and continuous evaluation of its mechanical properties is a necessity for long and safe operation. Standard tests require a collection of large-dimension samples coming from the precious and archive materials, usually produced as control segments.
Kapusňák, M., Petzová, J., Březina, M., Adamech, M.   +3 more
openaire   +4 more sources

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 1 2004

, 2004
GP consultation rates for influenza-like illness (ILI) in Ireland increased slightly during week 1, this may be partly due to the disruption in reporting during the Christmas and New Year period.
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Respiratory pathogens detected in specimens collected for COVID-19 surveillance in Zambia

Journal of Public Health in Africa
Background: In Zambia, knowledge on the landscape of respiratory pathogens that circulated during the coronavirus disease 2019 (COVID-19) pandemic is limited.
Martin Nyahoda, Ngonda Saasa, Katendi Changula, Walter Muleya, Zachariah Mupila, Chilufya Chikoti, Gift Moonga, Catherine Sutcliffe, Geoffrey Kwenda, Edgar Simulundu   +9 more
doaj   +1 more source