Results 91 to 100 of about 1,413,891 (297)

SARS-CoV-2 genomic surveillance using self-collected saliva specimens during occupational testing programs

Frontiers in Public Health
Continually emerging SARS-CoV-2 variants pose challenges to clinical and public health interventions, necessitating sustainable approaches to real-time variant monitoring.
Andrew T. Schnaubelt, David M. Brett-Major, Janet Williamson, Bailey Barcal, Julie Carstens, Ashley Peer, Michael Wiley, M. Jana Broadhurst   +7 more
doaj   +1 more source

Weekly Influenza Surveillance Report Weeks 51 & 52 2002

, 2003
The sentinel GP consultation rate for influenza-like illness remains at low levels. Influenza virus has not been detected this season in sentinel or non-sentinel specimens.
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Multiplex metagenomic sequencing for rapid viral pathogen identification and surveillance in clinical specimens

BMC Infectious Diseases
Abstract Background Rapid and accurate viral detection is essential for clinical diagnosis and effective outbreak surveillance. Traditional methods, including culture-based isolation and antigen tests, are time-consuming and limited by tissue tropism.
Su, Yu-Siang, Tsai, Wei-Hsiang, Wu, Han-Chieh, Chiu, Yueh-Tzu, Jiang, Ni-Rong, Lee, Chien-Yu, Cheng, Shu-Hsing, Huang, Chih-Ting, Chi, Chia-Yu, Lin, En-Ju, Kuo, Yi-Ping, Tsai, Wan-Ting, Tien, Chih-Feng, Liao, Yu-Chieh, Lee, Kuan-Lin, Chen, Feng-Jui, Yu, Guann-Yi   +16 more
openaire   +2 more sources

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 41 2003

, 2003
The first positive cases of influenza virus (4 influenza A H3N2) reported through the GP sentinel surveillance scheme for the 2003/2004 season were identified in week 41.
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Weekly Influenza Surveillance Report Week 44 2002 [PDF]

, 2002
To date, no laboratory confirmed cases of influenza have been identified during the 2002/2003-influenza season. There has been an increase in the number of positive RSV specimens from non-sentinel sources this season compared to the 2001/2002- influenza ...
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Genomic Variant Surveillance of SARS-CoV-2 Positive Specimens Using a Direct PCR Product Sequencing Surveillance (DPPSS) Method

Acta Medica Philippina
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of COVID-19 has significantly challenged the public health landscape in late 2019. After almost 3 years of the first ever SARS-CoV-2 case, the World Health Organization (WHO) declared the end of this global health emergency in May 2023.
Tuberon, Nicole Ann L., Heralde, Francisco M., Reportoso, Catherine C., Gaitano, Arturo L., Elopre, Wilmar Jun O., Fernandez, Kim Claudette J.   +5 more
openaire   +2 more sources

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source