Results 201 to 210 of about 2,041,158 (244)

AI Chatbot Use and Disclosure for Mental Health Among US Adolescents and Young Adults. [PDF]

JAMA Pediatr
McBain RK, Cantor JH, Breslau J, Diliberti M, Zhang LA, Zhang F, Burnett A, Kofner A, Rader B, Pataranutaporn P, Stein BD, Mehrotra A, Yu H.   +12 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Enhancing epidemic forecast usability for policymakers: A global mixed-methods study. [PDF]

PLOS Glob Public Health
Christen P, Ombajo LA, Cori A, Dawa J, Djaafara BA, Kimani TN, Schneider CMJ, van Elsland SL, Thumbi M, Veras M, Whittaker C, Whittles LK, Watson OJ.   +12 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Modifiable Determinants of Metabolic Syndrome in Middle-Aged Adults: A Cross-Sectional Analysis of a Nationally Representative Health Survey. [PDF]

Nurs Res Pract
Jang K.
europepmc   +1 more source

International practices and variability in right heart echocardiography: results from the RVNet(Work) international survey. [PDF]

Echo Res Pract
Magunia H, Augustine DX, Kovács A, Nicoara A, Keller M, Thijssen D, Hahn RT, Muraru D, Rudski L, Addetia K, Mukherjee M, van Dijk A, Denault A, Surkova E, Haddad F, Oxborough D.   +15 more
europepmc   +1 more source

An observational study of the Patient-Centered Outcomes Research Institute's switch from in-person to virtual research application review panels during the COVID-19 pandemic. [PDF]

Res Integr Peer Rev
Bloodworth R, Hemphill R, Forsythe LP, Mohan C, Nolton EC, Abadi P, Stewart LJ, Woodward KP.   +7 more
europepmc   +1 more source

Strengthening frontline capacity for skin neglected tropical diseases: Findings from a global survey. [PDF]

PLoS Negl Trop Dis
Anwar S, Freeman EE, Geutjes R, Fenenga C, Pathak P, Dagne DA, Gabrielli AF, Fuller LC, Ruiz Postigo JA.   +8 more
europepmc   +1 more source

Cognitive Testing of the People's Voice Survey Instrument to Assess Adults' and Adolescents' Experience in European Healthcare Systems. [PDF]

Healthcare (Basel)
Kūkoja K, Stars I, Briģis Ģ, Simões ML, Clarke-Deelder E, Villeruša A.   +5 more
europepmc   +1 more source

Pancreas Transplantation for Recipients with Type 2 Diabetes Mellitus: Results of an International Survey. [PDF]

Transplant Direct
Fridell JA, Uva PD, Kukla A, DeLonais-Parker A, Mansuri RF, Axelrod D, Dunn T, Niederhaus SV, Parsons R, Pleass H, Paraskevas S, Rickels MR, Stratta RJ, Ventura-Aguiar P, Woodside KJ, Lentine KL.   +15 more
europepmc   +1 more source