Results 91 to 100 of about 4,808,505 (289)
A Mixture Model for Survival Data with Both Latent and Non-Latent Cure Fractions
StatsOne of the most popular cure rate models in the literature is the Berkson and Gage mixture model. A characteristic of this model is that it considers the cure to be a latent event.
Eduardo Yoshio Nakano +2 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study
The World Journal of Men's HealthPurpose: Androgen signaling is associated with various secondary cancer, which could be promising for potential treatment using androgen deprivation therapy (ADT). This study investigated whether ADT use was associated with secondary cancers other than
Jae Heon Kim +3 more
doaj +1 more source
JTAM (Jurnal Teori dan Aplikasi Matematika)Multiple myeloma is a type of blood cancer that attacks plasma cells in the bone marrow and affects the immune system. This study analyzes the survival time of patients with multiple myeloma using Type 1 censored exponential distributed parameter ...
Cahya Arsyika Wahyu Subekti +4 more
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
A Bivariate Copula–Driven Multi-State Model for Statistical Analysis in Medical Research
MathematicsWe develop and evaluate a copula-based multistate model for illness–death processes with dependent transition times. The framework couples Cox proportional hazards models for the marginal transition intensities with Archimedean copulas to capture ...
Hugo Brango +2 more
doaj +1 more source
The impact of FDI on firm survival in Italy [PDF]
The aim of the analysis is to investigate the impact of inward FDI on Italian manufacturing and services firm survival. The paper is organized in two steps.
Anna Ferragina +2 more
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