Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A Mixture Model for Survival Data with Both Latent and Non-Latent Cure Fractions
StatsOne of the most popular cure rate models in the literature is the Berkson and Gage mixture model. A characteristic of this model is that it considers the cure to be a latent event.
Eduardo Yoshio Nakano +2 more
doaj +1 more source
Modeling Big Medical Survival Data Using Decision Tree Analysis with Apache Spark [PDF]
, 2019 In many medical studies, an outcome of interest is not only whether an event occurred, but when an event occurred; and an example of this is Alzheimer’s disease (AD).
Abdelqader, Ikhlas +4 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Recurrence and survival of patients with stage III endometrial cancer after radical surgery followed by adjuvant chemo- or chemoradiotherapy: a systematic review and meta-analysis [PDF]
, 2022 Si Cao +5 more
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A COMPARISON OF MULTIPLICATIVE AND ADDITIVE HAZARD MODELS USING THE HAZARD AND SURVIVAL RATIO
Media StatistikaThe Cox multiplicative hazards regression and Aalen additive hazards regression models are widely used for survival data analysis. While the Cox model emphasizes hazard ratios or relative risks, the Aalen model focuses on relative survival or excess ...
Danardono Danardono, Gunardi Gunardi
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of 579 patients [PDF]
, 1994 Ronald C. Newland +4 more
openalex +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source