Results 81 to 90 of about 4,850,533 (302)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma
CPT: Pharmacometrics & Systems PharmacologyWe employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented ...
Kevin Atsou +4 more
doaj +1 more source
Frontiers in Medical TechnologyBackgroundThis study aims to develop a machine learning model to predict the 30-day mortality risk of hospitalized COVID-19 patients while leveraging federated learning to enhance data privacy and expand the model's applicability.
Yueh-Chen Hsieh +8 more
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Frontiers in Public HealthBackgroundDespite expanded antiretroviral therapy (ART) coverage in China, AIDS remains a major public health challenge. This study aimed to assess survival outcomes and identify factors influencing survival time among HIV/AIDS patients receiving ART ...
Yao Huang +6 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Survival Analysis as Imprecise Classification with Trainable Kernels
MathematicsSurvival analysis is a fundamental tool for modeling time-to-event data in healthcare, engineering, and finance, where censored observations pose significant challenges.
Andrei Konstantinov +5 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Medical SciencesBackground: Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disorder with highly variable progression and survival. Identifying early prognostic indicators is essential for patient stratification and management.
Anca Motataianu +6 more
doaj +1 more source
The Comparison of Survival Rates between Narrow Diameter Implants and Standard Diameter Implants: An Updated Meta-analysis [PDF]
, 2023 Kimia Ganji +3 more
openalex +1 more source