Results 91 to 100 of about 59,431 (239)

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

open access: yesPeriodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva   +2 more
wiley   +1 more source

The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro [PDF]

open access: yes, 2011
Background: Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistance to conventional therapeutic ...
Philipp Lechler   +6 more
core   +3 more sources

Modulatory Effects of Folic Acid and Dental Pulp Stem Cell‐Derived Exosomes on Gene Expression in a Periodontal Injury Model

open access: yesNatural Sciences, Volume 6, Issue 2, April 2026.
Dental pulp stem cellderived exosomes and folic acid are evaluated for their effects on gene expression in an in‐vitro periodontal injury model. Human gingival fibroblasts subjected to oxidative and mechanical injury are treated with folic acid, exosomes, or their combination.
Saghar Zarei   +4 more
wiley   +1 more source

Lentiviral manipulation of gene expression in human adult and embryonic stem cells [PDF]

open access: yes, 2006
Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery.
Boshoff, C.   +5 more
core   +1 more source

From Single‐Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This graphical abstract illustrates an integrative analysis of single‐cell RNA‐seq data in CKD. DEGs were subsequently identified as candidate genes via Mendelian randomization analysis and combined with MAGMA analysis, ITCH was identified as a key gene.
Xia Zhang   +7 more
wiley   +1 more source

Survivin在T细胞非霍奇金淋巴瘤组织中的表达及临床意义

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2006
【目的】了解生存蛋白Survivin在T细胞非霍奇金淋巴瘤(T—NHL)中的表达,以及Survivin表达与预后的关系。【方法】用免疫组化S-P法检测83例T细胞NHL组织Survivin表达情况,分析Survivin表达与预后的关系。【结果】Survivin表达阴性10例(12%),表达阳性73例(88%),Survivin表达与病理类型、性别、年龄、B症状、结外病变数、PS、分期、LDH水平、IPI等临床特征均无相关性(P〉0.05)。78例接受了化疗,大多数采用CHOP方案化疗,全组CR率45 ...
黄慧强   +5 more
doaj  

The prognostic role of VEGF in head and neck squamous cell carcinoma [PDF]

open access: yes, 2017
Emerging from potentially malignant disorders that in most cases will never become cancerous, head and neck squamous cell carcinoma (HNSCC) is a cancer that is extremely difficult to diagnose early.
Mathew, Rohit Thomas
core  

FNDC1 Competitively Binds Gβ2 to Suppress the β‐Catenin–Destruction Complex and Promote Gastric Cancer Malignancy

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
FNDC1 competitively binds Gβ2 to suppress the β‐catenin–destruction complex and promote the malignant behavior of gastric cancer (GC) by the following mechanism: elevated FNDC1 competes with Dvl for binding to Gβ2, thereby reducing Dvl–Gβ2 interaction; this reduction inhibits Dvl degradation in the cytoplasm; increased Dvl recruits Axin1, thereby ...
Wenyu Gao   +9 more
wiley   +1 more source

Biomarkers of basal cell carcinoma resistance to methyl-aminolevulinate photodynamic therapy [PDF]

open access: yes, 2019
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Gilaberte, Yolanda   +6 more
core   +4 more sources

The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease

open access: yesPulmonary Circulation, 2019
The reversibility of pulmonary arterial hypertension (PAH) determines the operability of congenital heart disease (CHD) complicating with PAH, but it lacks a method for evaluating the reversibility.
Gang Li   +7 more
doaj   +1 more source

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