Results 91 to 100 of about 60,299 (235)

Survivin在T细胞非霍奇金淋巴瘤组织中的表达及临床意义

Zhongshan Daxue xuebao. Yixue kexue ban, 2006
【目的】了解生存蛋白Survivin在T细胞非霍奇金淋巴瘤（T—NHL）中的表达，以及Survivin表达与预后的关系。【方法】用免疫组化S-P法检测83例T细胞NHL组织Survivin表达情况，分析Survivin表达与预后的关系。【结果】Survivin表达阴性10例（12％），表达阳性73例（88％），Survivin表达与病理类型、性别、年龄、B症状、结外病变数、PS、分期、LDH水平、IPI等临床特征均无相关性（P〉0．05）。78例接受了化疗，大多数采用CHOP方案化疗，全组CR率45 ...
黄慧强, 彭玉龙, 黄欣, 潘战和, 侯景辉, 吴秋良   +5 more
doaj  

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2020
Background Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventions.
Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wenbin Liu, Wei Li   +6 more
doaj   +1 more source

The prognostic role of VEGF in head and neck squamous cell carcinoma [PDF]

, 2017
Emerging from potentially malignant disorders that in most cases will never become cancerous, head and neck squamous cell carcinoma (HNSCC) is a cancer that is extremely difficult to diagnose early.
Mathew, Rohit Thomas
core  

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

The expression of survivin in irreversible pulmonary arterial hypertension rats and its value in evaluating the reversibility of pulmonary arterial hypertension secondary to congenital heart disease

Pulmonary Circulation, 2019
The reversibility of pulmonary arterial hypertension (PAH) determines the operability of congenital heart disease (CHD) complicating with PAH, but it lacks a method for evaluating the reversibility.
Gang Li, Han Zhang, Lei Zhao, Yaozhong Zhang, Daole Yan, Yinglong Liu, Junwu Su, Xiangming Fan   +7 more
doaj   +1 more source

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC.

PLoS ONE, 2020
Treating pancreatic ductal adenocarcinoma (PDAC) remains a major hurdle in the field of oncology. Less than half of patients respond to frontline chemotherapy and the pancreatic tumor microenvironment limits the efficacy of immunotherapeutic approaches ...
Matthew Brown, Wanbin Zhang, Deyue Yan, Rajath Kenath, Le Le, He Wang, Daniel Delitto, David Ostrov, Keith Robertson, Chen Liu, Kien Pham   +10 more
doaj   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

BMC Neuroscience, 2010
Background Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein.
Eisch Amelia, Cremer Harold, Reumers Veerle, Baekelandt Veerle, Moons Michaël, Antonucci Flavia, Cremer Jonathan, DeVriese Astrid, D'Hooge Rudi, Balschun Detlef, Ahmed Tariq, Coremans Vanessa, Lagace Diane, Janssens Tom, Bozzi Yuri, Caleo Matteo, Conway Edward M   +16 more
doaj   +1 more source

Celecoxib in breast cancer prevention and therapy. [PDF]

, 2018
Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively
Cao, Wei, Hao, Qiongyu, Li, Jieqing, Vadgama, Jaydutt V, Wu, Yong   +4 more
core  

Antagonizing CD105 enhances radiation sensitivity in prostate cancer. [PDF]

, 2018
Radiation therapy is the primary intervention for nearly half of the patients with localized advanced prostate cancer and standard of care for recurrent disease following surgery.
Andres, Allen, Angara, Bryan, Bhowmick, Neil A, Duong, Frank, Gottlieb, Roberta, Haldar, Subhash, Liu, Zhenqiu, Madhav, Anisha, Mishra, Rajeev, Zumsteg, Zachary S   +9 more
core   +1 more source