Results 81 to 90 of about 59,883 (231)
How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]
, 2013 Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core +2 more sources
Targeting survivin in cancer [PDF]
Cancer Letters, 2013 With almost 4000 citations in Medline in a little over 10 years, survivin has certainly kept scores of investigators busy worldwide. Tangible progress has been made in revealing the multiple functions of survivin, uncovering their wirings as integrated cellular networks, and mapping their exploitation in virtually every human tumor, in vivo ...
openaire +2 more sources
Andrology, EarlyView.ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino +5 more
wiley +1 more source
Chinese Journal of Lung Cancer, 2010 Background and objective Lung cancer is one of the most common cancers worldwide and causes more deaths per year than other cancers. Autoantibody was one hotspot in tumor marker research.
Li MA +5 more
doaj
Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer
Diagnostic Pathology, 2012 Background As a known regulator of apoptosis, survivin has positive relationship with lymphatic metastasis in breast cancer. This study aims to detect the difference in expression between survivin and vascular endothelial growth factor-C (VEGF-C) in ...
Cai Xiaopeng +5 more
doaj +1 more source
Journal of International Medical Research, 2020 Objective Recent studies demonstrated that circulating tumor cells (CTCs) contribute to the metastasis of prostate cancer. Survivin knockout could inhibit epithelial-mesenchymal transition (EMT) and suppress several metastatic tumors.
Faying Yang +6 more
doaj +1 more source
Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis
Scientific Reports, 2021 Sepsis is a dysregulated host response to infection related to devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology.
Marianna Miliaraki +18 more
doaj +1 more source
Cancer Science, EarlyView.Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee +4 more
wiley +1 more source
Survivin expression and its clinical significance in pancreatic cancer
BMC Cancer, 2005 Background Survivin, an inhibitor of apoptosis is expressed in several human cancers. Its expression is known to be associated with poor clinical outcome, but not widely studied in pancreatic cancer.
Lee Kyung Shik +8 more
doaj +1 more source
OCT4 positively regulates Survivin expression to promote cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma. [PDF]
PLoS ONE, 2012 BACKGROUND: OCT4 and Survivin are important factors for cancer cell proliferation, renewal and dedifferentiation, and correlate with resistance to radiotherapy and chemotherapy in most human cancers, but their regulatory mechanisms are not well known ...
Chunguang Li +9 more
doaj +1 more source