Results 71 to 80 of about 41,070 (225)

Expression of Survivin and Its Spliced Variants in Bladder Tumors as a Potential Prognostic Marker

Urology Journal, 2009
<p><strong>Introduction: </strong>Survivin, a novel inhibitor of apoptosis, is re-expressed in a vast majority of human cancers and is widely considered as a diagnostic marker of cancers.
Ardalan Ozhand, Mahmoud Parvin, Nazila Nouraee, Seyed Javad Mowla, Seyed Amir Mohsen Ziaee, Nasim Hatefi   +5 more
doaj  

Survivin expression and its clinical significance in pancreatic cancer

BMC Cancer, 2005
Background Survivin, an inhibitor of apoptosis is expressed in several human cancers. Its expression is known to be associated with poor clinical outcome, but not widely studied in pancreatic cancer.
Lee Kyung Shik, Hong Young Seon, Kang Jin-Hyoung, Jung Ji-Han, Lee Hee-Jung, Park Gyeong-sin, Lee Myung Ah, Kim Dong-gu, Kim Seung-Nam   +8 more
doaj   +1 more source

The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance

Frontiers in Cell and Developmental Biology, 2022
Quantitative analysis and regulating gene expression in cancer cells is an innovative method to study key genes in tumors, which conduces to analyze the biological function of the specific gene.
Changping Deng, Fabiao Hu, Zhangting Zhao, Yiwen Zhou, Yuping Liu, Tong Zhang, Shihui Li, Wenyun Zheng, Wenliang Zhang, Tianwen Wang, Xingyuan Ma   +10 more
doaj   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils [PDF]

, 2004
Survivin has received great attention due to its expression in many human tumors and its potential as a therapeutic target in cancer. Survivin expression has been described to be cell cycle-dependent and restricted to the G2-M checkpoint, where it ...
Zangemeister-Wittke, Uwe, Sibylla Martinelli, Martinelli, Sibylla, Yousefi, Shida, Fey, Martin F, Frank Altznauer, Simon, Hans-Uwe, Christoph Mueller, Uwe Zangemeister-Wittke, Mueller, Christoph, Hans-Uwe Simon, Thürig, Christine, Vogt, Peter, Inès Schmid, Shida Yousefi, Martin H. Schöni, Altznauer, Frank, Schöni, Martin H, Christine Thürig, Martin F. Fey, Edward M. Conway, Schmid, Inès, Conway, Edward M, Peter Vogt   +23 more
core   +2 more sources

Expressions of survivin and the splice variants survivin-2B and survivin-Delta Ex3 in bladder cancer and their clinical significance

Chinese Journal of Cancer, 2009
Studies on survivin over the past 5 years have shown that survivin participates in the genesis of several human cancers, including bladder cancer. Recent studies have indicated that survivin splice variants appeared to have unique subcellular localizations and functions as well.
Xue-Feng, He, Duan-Gai, Wen, Jian-Quan, Hou, Jun, He, Jian-Nong, Cen   +4 more
openaire   +2 more sources

Clinical Significance and Diagnostic Value of Survivin Autoantibody in Non-small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2010
Background and objective Lung cancer is one of the most common cancers worldwide and causes more deaths per year than other cancers. Autoantibody was one hotspot in tumor marker research.
Li MA, Wentao YUE, Lina ZHANG, Yue WANG, Chunyan ZHANG, Xuehui YAN   +5 more
doaj  

Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2009
Background p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis.
Yamamoto Satoshi, Anami Kentaro, Tokuishi Keita, Miyawaki Michiyo, Chujo Masao, Yamashita Shin-ichi, Kawahara Katsunobu   +6 more
doaj   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Epithelial-mesenchymal transition of circulating tumor cells in prostate cancer is promoted by survivin

Journal of International Medical Research, 2020
Objective Recent studies demonstrated that circulating tumor cells (CTCs) contribute to the metastasis of prostate cancer. Survivin knockout could inhibit epithelial-mesenchymal transition (EMT) and suppress several metastatic tumors.
Faying Yang, Jianhua Ma, Jianghou Wan, Wuhua Ha, Cheng Fang, Huaiquan Lu, Wei Zhang   +6 more
doaj   +1 more source