Results 61 to 70 of about 41,070 (225)

Survivin – The inconvenient IAP [PDF]

Seminars in Cell & Developmental Biology, 2015
Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has consistently defied assumptions, refuted predictions and challenged paradigms. Despite its more than 5500 citations currently in Medline, the biology of survivin has remained fascinatingly complex, its exploitation in human disease, most notably cancer ...
openaire   +2 more sources

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Analytical Cellular Pathology, 2010
Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of ...
Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos   +9 more
doaj   +1 more source

Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia

Haematologica, 2007
Background and Objectives Impaired apoptosis, mediated by members of the inhibitor of apoptosis proteins (IAP) family such as survivin, is thought to contribute to leukemic cell survival. In contrast to low expression of survivin in normal differentiated
Anja Troeger, Meinolf Siepermann, Gabriele Escherich, Roland Meisel, Reinhardt Willers, Sonja Gudowius, Thomas Moritz, Hans-Juergen Laws, Helmut Hanenberg, Ulrich Goebel, Gritta E. Janka-Schaub, Csaba Mahotka, Dagmar Dilloo   +12 more
doaj   +1 more source

Survivin delta Ex3 overexpression in thyroid malignancies. [PDF]

PLoS ONE, 2014
CONTEXT: Thyroid cancer incidence has increased significantly during the past decades and is the most common type of endocrine malignancy. Many factors in thyroid cancers were studied as independent predictors of a poor prognosis.
Joanna Waligórska-Stachura, Mirosław Andrusiewicz, Nadia Sawicka-Gutaj, Maciej Biczysko, Anna Jankowska, Marta Kubiczak, Agata Czarnywojtek, Elżbieta Wrotkowska, Marek Ruchała   +8 more
doaj   +1 more source

Aberrant Alternative Polyadenylation is Responsible for Survivin Up-regulation in Ovarian Cancer

Chinese Medical Journal, 2016
Background: Survivin is an oncoprotein silenced in normal mature tissues but reactivated in serous ovarian cancer (SOC). Although transcriptional activation is assumed for its overexpression, the long 3'-untranslated region (3'-UTR) in survivin gene ...
Xiang-Jun He, Qi Zhang, Li-Ping Ma, Na Li, Xiao-Hong Chang, Yu-Jun Zhang   +5 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する [PDF]

, 2007
t(17;19)急性リンパ性白血病acute lymphoblastic leukemia (t(17;19)^+ ALL)はE2A-HLFの抗アポトーシス能により白血病化する. t(17;19)^+ ALLはsurvivinが高発現し, E2A-HLFドミナントネガティブ変異dominant negative (dn)の導入でsurvivinの発現が抑制される一方, t(17;19)を有しないALL (t(17;19)^- ALL)細胞にE2A-HLFを導入するとsurvivinが高発現した ...
奥谷, 真由子, オクヤ, マユコ
core  

Quantitative analysis of survivin in colorectal adenocarinoma: increased expression and correlation with telomerase activity [PDF]

, 2008
The aims of the present study are to quantitatively analyze survivin expression, its clinicopathologic roles, and correlation with telomerase activity in a large cohort of patients with colorectal adenocarcinoma.
Lam, Alfred King-Yin, Lam, Alfred, Saleh, Said, Ho, Yik-Hong, Smith, Robert, Smith, Robert Anthony   +5 more
core   +1 more source