Results 51 to 60 of about 41,070 (225)

Survivin in the Human Hair Follicle [PDF]

Journal of Investigative Dermatology, 2007
No
Botchkareva, Natalia V., Ahluwalia, G., Kahn, M., Shander, D.   +3 more
openaire   +4 more sources

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Survivin Hakkında Bilinenler: Survivin İle İlgili Türkiye’de Yapılmış Olan Çalışmalar [PDF]

, 2015
İnsanlarda 3 intron ve 4 ekzondan meydana gelen Survivin geni kromozomun 17q25 bölgesinde yer alan 14,7 kb uzunluğunda olan ve 142 aminoasitlik, 16,5 KD ağırlığında proteini kodlayan bir gendir. Survivin; akciğer, böbrek, cilt, endometriyum, mide, kolon,
Yüce, Hüseyin, Bircan, Duygu, Özmerdivenli, Recep, Eröz, Recep   +3 more
core   +2 more sources

Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2009
Background Survivin is a structurally and functionally unique member of the inhibitor of apoptosis protein (IAP) family. It plays an important role, not only in regulating mitosis but also in inhibiting apoptosis.
Li Wei, Zhao Cheng-Ling, Chen Yu-Qing
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Survivin in ovary tumors

Polish Gynaecology, 2015
Survivin is a member of the inhibitor of apoptosis protein (IAP) family which are selectively overexpressed in human neoplasms, and its expression has been shown to be connected with cell proliferation. We analyzed survivin expression in ovarian epithelial neoplasms to evaluate its role in the development of ovarian tumors.Immunohistochemistry assays ...
Danuta, Plewka, Beata, Jakubiec-Bartnik, Michał, Morek, Edyta, Bogunia, Marek, Bienioszek, Hubert, Wolski, Daniel, Kotrych, Karolina, Dziekan, Agnieszka, Seremak-Mrozikiewicz, Andrzej, Plewka   +9 more
openaire   +2 more sources

OCT4 positively regulates Survivin expression to promote cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma. [PDF]

PLoS ONE, 2012
BACKGROUND: OCT4 and Survivin are important factors for cancer cell proliferation, renewal and dedifferentiation, and correlate with resistance to radiotherapy and chemotherapy in most human cancers, but their regulatory mechanisms are not well known ...
Chunguang Li, Yan Yan, Weidan Ji, Longlong Bao, Haihua Qian, Lei Chen, Mengchao Wu, Hezhong Chen, Zhigang Li, Changqing Su   +9 more
doaj   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Molecular Cancer, 2010
Background Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular chaperone Hsp90 binds and stabilizes
Lyu Kevin W, Kanwar Jagat R, Cheng Li-Ting, Chen Huang-Hui, Cheung Chun Hei Antonio, Chang Jang-Yang   +5 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source