Scientific Reports, 2022 Overexpression of survivin is frequently observed in human malignancies and is associated with poor prognosis. The present study found that survivin is highly expressed in nasopharyngeal carcinoma (NPC) tumor tissues.
Xin Dong +6 more
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High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy [PDF]
, 2012 Purpose: To investigate the prognostic value of survivin expression in pretreatment specimens from patients with anal cancer treated with concurrent 5-FU and mitomycin C-based chemoradiation (CRT).
Rave-Fränk, Marget +15 more
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The detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancer. [PDF]
PLoS ONE, 2013 Survivin is a component of the chromosomal passenger complex (CPC) that is essential for accurate chromosome segregation. Interfering with the function of Survivin in mitosis leads to chromosome segregation errors and defective cytokinesis.
Masato Hori +9 more
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Borealin : a novel chromosomal passenger required for stability of the bipolar mitotic spindle [PDF]
, 2004 The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex.
Erich A. Nigg +26 more
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Neoplasia: An International Journal for Oncology Research, 2000 Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase ...
Jun Chen +11 more
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HLA-A24 and survivin: possibilities in therapeutic vaccination against cancer
Journal of Translational Medicine, 2006 Recently, it was described that an HLA-A24 restricted peptide derived from the survivin splice variant survivin-2B can be recognized by CD8(+) cytotoxic T-cells. The identification of an HLA-A24 epitope is critical for survivin-based immunotherapy as HLA-
Becker Jürgen C +3 more
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The role of Galectin-3 and Survivin in invasion and drug resistance in human cancer [PDF]
, 2003 Galectin-3 is an apoptosis-related gene previously found to be over-expressed in invasive tumours and to cause in v itroinvasiveness and metastasis in colon, breast and thyroid follicular cancer cells.
Linehan, Rasha
core +2 more sources
Scientific Reports, 2020 The role of subcellular survivin compartmentalization in the biology and prognosis of prostate cancer is unclear. We therefore investigated subcellular localization of survivin in more than 3000 prostate cancer patients by quantitative ...
Jan K. Hennigs +10 more
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Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. [PDF]
PLoS ONE, 2013 The inhibitor of apoptosis protein survivin is expressed in most cancers. Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth.
Helty Adisetiyo +10 more
doaj +1 more source
Bayesian Analysis of MicroScale Thermophoresis Data to Quantify Affinity of Protein: Protein Interactions with Human Survivin [PDF]
, 2017 A biomolecular ensemble exhibits different responses to a temperature gradient depending on its diffusion properties. MicroScale Thermophoresis technique exploits this effect and is becoming a popular technique for analyzing interactions of biomolecules ...
Stadler, Volker, +21 more
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