Results 11 to 20 of about 59,883 (231)

Expression of survivin and its splice variants survivin-2B and survivin-ΔEx3 in breast cancer [PDF]

British Journal of Cancer, 2004
Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cancer and axillary nodal metastases ...
Ryan, B, O'Donovan, N, Browne, B, O'Shea, C, Crown, J, Hill, A D K, McDermott, E, O'Higgins, N, Duffy, M J   +8 more
openaire   +2 more sources

Loss of cytoplasmic survivin expression is an independent predictor of poor prognosis in radically operated prostate cancer patients

Cancer Medicine, 2020
Survivin is an inhibitor of apoptosis. Aberrant survivin expression occurs in malignant tumors and has often been linked to unfavorable patient outcome. Here we analyzed 12 432 prostate cancers by immunohistochemistry.
Franziska Büscheck, Mariam Sulimankhil, Nathaniel Melling, Doris Höflmayer, Claudia Hube‐Magg, Ronald Simon, Cosima Göbel, Andrea Hinsch, Sören Weidemann, Jacob R. Izbicki, Frank Jacobsen, Tim Mandelkow, Niclas C. Blessin, Christina Möller‐Koop, Florian Lutz, Florian Viehweger, Katharina Möller, Guido Sauter, Maximilian Lennartz, Eike Burandt, Patrick Lebok, Sarah Minner, Sarah Bonk, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Christoph Fraune   +26 more
doaj   +1 more source

High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy [PDF]

, 2012
Purpose: To investigate the prognostic value of survivin expression in pretreatment specimens from patients with anal cancer treated with concurrent 5-FU and mitomycin C-based chemoradiation (CRT).
Distel, Luitpold Valentin Rudolf, Falk, Stefan, Fraunholz, Ingeborg, Kohler, Daniela, Rave-Fränk, Margret, Rödel, Claus, Rödel, Franz   +6 more
core   +2 more sources

Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. [PDF]

PLoS ONE, 2012
BACKGROUND:The prognostic significance of survivin for survival of patients with esophageal squamous cell carcinoma (ESCC) remains controversial. Thus, meta-analysis of the literatures was performed in order to demonstrate its expression impact on ESCC ...
Chunguang Li, Zhigang Li, Maoling Zhu, Tiejun Zhao, Ling Chen, Weidan Ji, Hezhong Chen, Changqing Su   +7 more
doaj   +1 more source

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]

, 2015
Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A, Brun, SN, Conway, EM, Crawford, JR, Esparza, LA, Garcia, G, Grant, GA, Greene, MI, Huang, J-M, Levy, ML, Li, X-N, Markant, SL, Nakano, I, Pavlyukov, MS, Smith, LH, Terry, D, Wang, Q, Wechsler-Reya, RJ   +17 more
core   +2 more sources

Ser81 Survivin Induced Protein Kinase A (PKA)-dependent Phosphatidylinositol 3-kinase (PI3K) Activity

Indonesian Biomedical Journal, 2014
BACKGROUND: Our previous report showed that phosphorylated-survivin at Ser81 induces survivin back loop to activate protein kinase A (PKA) in the cytoprotection mechanism.
Ferry Sandra, Roya Khosravi-Far
doaj   +1 more source

Age‐Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus [PDF]

Aging Cell
Aging in females reduces the number of implantation sites and leads to specific, compartment‐dependent changes in components of the chromosomal passenger complex (pIncenp, Aurora B, Survivin, Borealin) during mouse uterine implantation and decidualization.
Golal E, Balci C, Acar N.
europepmc   +2 more sources

Survivin S81A Enhanced TRAIL's Activity in Inducing Apoptosis

Indonesian Biomedical Journal, 2010
BACKGROUND: Survivin is rarely expressed in normal healthy adult tissues, however, it is upregulated in the majority of cancers. Survivin, which belongs to IAPs family, has been widely reported to protect cells from apoptosis by inhibiting caspases ...
Ferry Sandra, Roya Khosravi-Far
doaj   +1 more source

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity [PDF]

, 2009
Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death.
Barrett, Rachel M.A., Osborne, Toby P., Wheatley, Sally P.   +2 more
core   +1 more source

Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance

Scientific Reports, 2022
Overexpression of survivin is frequently observed in human malignancies and is associated with poor prognosis. The present study found that survivin is highly expressed in nasopharyngeal carcinoma (NPC) tumor tissues.
Xin Dong, Wenbin Liu, Xiaoying Li, Yu Gan, Li Zhou, Wei Li, Li Xie   +6 more
doaj   +1 more source