Results 1 to 10 of about 41,070 (225)

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

BMC Neuroscience, 2010
Background Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein.
Eisch Amelia, Cremer Harold, Reumers Veerle, Baekelandt Veerle, Moons Michaël, Antonucci Flavia, Cremer Jonathan, DeVriese Astrid, D'Hooge Rudi, Balschun Detlef, Ahmed Tariq, Coremans Vanessa, Lagace Diane, Janssens Tom, Bozzi Yuri, Caleo Matteo, Conway Edward M   +16 more
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Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients

Journal of Translational Medicine, 2009
Background We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B.
Yamaguchi Akira, Miyazaki Akihiro, Idenoue Satomi, Hirohashi Yoshihiko, Torigoe Toshihiko, Kobayashi Jun-ichi, Hiratsuka Hiroyoshi, Sato Noriyuki   +7 more
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Survivin induces defects in apoptosis in eosinophils in intestine with food allergy

Innate Immunity, 2019
Survivin is an anti-apoptosis protein that may be associated with the development of eosinophilia; the latter is associated with the pathogenesis of many immune disorders.
Han Gao, Bai-Sui Feng, Jiang-Qi Liu, Li-Hua Mo, Xiao-Rui Geng, Yuan Xiao, Yuan-Yi Zhang, Jing-Yi Hong, Zhan-ju Liu, Zhi-Gang Liu, Yisheng Feng, Ping-Chang Yang   +11 more
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The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair

Cellular Physiology and Biochemistry, 2015
Background/Aims: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We investigated the effects of YM155, a small molecule inhibitor of survivin expression, on the radiosensitivity of human non ...
Songliu Hu, Songbin Fu, Xiangying Xu, Lin Chen, Jianyu Xu, Bin Li, Yuanyuan Qu, Hongyang Yu, Shan Lu, Wenxin Li   +9 more
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Expression and Clinical Significance of Antiapoptotic Gene (Survivin) in NB4 and Acute Promyelocytic Leukemia Cells

The Scientific World Journal, 2012
To study survivin gene expression in APL cells and to explore its correlation with clinical manifestations. PML/RARα and survivin mRNA expression were analysed using RT-PCR.
Jun Xue, Xiao-Jing Xie, Mao-Fang Lin
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Upregulation of Survivin in G2/M Cells and Inhibition of Caspase 9 Activity Enhances Resistance in Staurosporine-Induced Apoptosis

Neoplasia: An International Journal for Oncology Research, 2004
Survivin, a member of the inhibitor of apoptosis (IAP) gene family, plays an important role in both the regulation of cell cycle and the inhibition of apoptosis, and is frequently overexpressed in many tumor types.
Anmol Chandele, Vandna Prasad, Jayashree C. Jagtap, Ravi Shukla, Padma R. Shastry   +4 more
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Effect of shRNA Survivin-mediated Inhibition of Proliferation in A549 Cells

Chinese Journal of Lung Cancer, 2011
Background and objective Survivin is a member of the inhibitor of apoptosis family of proteins. The Survivin protein is highly expressed in most human tumors, but it is completely absent in terminally differentiated cells.
Lihong WU, Jinhe WANG, Qian WANG, Dongdong JIA, Jianqin LIANG   +4 more
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Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4+ cells

Cell Communication and Signaling
Background Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine 4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene expression control during cell differentiation.
Venkataragavan Chandrasekaran, Karin M. E. Andersson, Malin Erlandsson, Shuxiang Li, Torbjörn Nur Olsson, Maria-Jose Garcia-Bonete, Eric Malmhäll-Bah, Pegah Johansson, Gergely Katona, Maria I. Bokarewa   +9 more
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Study of the Expression of Survivin & Its Splice Variants; ΔEx3, 2b and 3b as Diagnostic Molecular Markers in Breast Cancer

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2009
Introduction: Survivin is a new member of the Inhibitor Apotosis Protein family (IAP) which plays an important role in the regulation of both cell cycle and apoptosis.
E Babaei, S Moniri Javadhesari, MA Hosseinpour Feizi, V Montazeri, M Halimi   +4 more
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应用RNAi技术沉默survivin基因对肝癌细胞系BEL-7404生长的影响

Zhongguo shiyan zhenduanxue, 2011
目的为研究生存素survivin基因的功能及肝细胞癌（HCC）的基因治疗策略。构建针对survivin基因的siR-NA的表达载体,转染肝癌细胞系BEL-7404后评价其对survivin基因表达的抑制作用。方法依据survivin基因设计siRNA片断,构建pGenesil-1/survivin表达载体,脂质体LipofectamineTM 2000转染BEL-7404细胞。实时定量聚合酶链反应从基因转录水平检测survivin基因的表达率,应用免疫组织化学的方法检测肝癌细胞系BEL ...
廖艳, 袁晟光, 廖维甲, 覃理灵, 梅铭惠, 陈谦   +5 more
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