Results 21 to 30 of about 41,070 (225)

Phosphorylation Modulates Survivin Function in Behcet’s Disease [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Survivin is critical for proliferation, maturation, homeostasis and differentiation of effector and memory lymphocytes. In this study the baculoviral inhibitors of apoptosis proteins (IAPs) repeat containing 5 (BIRC5) mRNA, survivin, and ...
Yasamin Pahlavan, Naser Samadi, Khalil Ansarin, Alireza Khabbazi   +3 more
doaj   +1 more source

Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27

iScience, 2023
Summary: This study investigates the role of survivin in epigenetic control of gene transcription through interaction with the polycomb repressive complex 2 (PRC2).
Maja Jensen, Venkataragavan Chandrasekaran, María-José García-Bonete, Shuxiang Li, Atsarina Larasati Anindya, Karin Andersson, Malin C. Erlandsson, Nina Y. Oparina, Björn M. Burmann, Ulrika Brath, Anna R. Panchenko, Maria Bokarewa I., Gergely Katona   +12 more
doaj   +1 more source

Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium. [PDF]

PLoS ONE, 2013
Survivin is an inhibitor of apoptosis and its over expression is associated with poor prognosis in several malignancies. While several studies have analyzed survivin expression in esophageal squamous cell carcinoma, few have focused on esophageal ...
Usha Malhotra, Ali H Zaidi, Juliann E Kosovec, Pashtoon M Kasi, Yoshihiro Komatsu, Christina L Rotoloni, Jon M Davison, Clint R, Irvin, Toshitaka Hoppo, Katie S Nason, Lori A Kelly, Michael K Gibson, Blair A Jobe   +13 more
doaj   +1 more source

Refining the Multivariable Predictive-Prognostic PREDICTR-OPC Model for Survival in Surgical Escalation for Oropharyngeal Squamous Cell Carcinoma. [PDF]

Laryngoscope
The PREDICTR‐OPC model is the only prognostic classifier for oropharyngeal squamous cell carcinoma (OPSCC) that also predicts surgical outcomes. This study demonstrates that removing survivin from the model preserves its prognostic and predictive performance, with comparable discrimination, calibration, and clinical utility across training and ...
Zhang LL, Kristunas C, Robinson CM, Brooks JM, Sitch AJ, Winter SC, Weir J, Matthews P, Jones TM, Hunter K, Golusinski P, Shah KA, Thavaraj S, West CM, Haider S, Odell E, Nankivell P, von Zeidler SV, Mehanna H.   +18 more
europepmc   +2 more sources

Loss of cytoplasmic survivin expression is an independent predictor of poor prognosis in radically operated prostate cancer patients

Cancer Medicine, 2020
Survivin is an inhibitor of apoptosis. Aberrant survivin expression occurs in malignant tumors and has often been linked to unfavorable patient outcome. Here we analyzed 12 432 prostate cancers by immunohistochemistry.
Franziska Büscheck, Mariam Sulimankhil, Nathaniel Melling, Doris Höflmayer, Claudia Hube‐Magg, Ronald Simon, Cosima Göbel, Andrea Hinsch, Sören Weidemann, Jacob R. Izbicki, Frank Jacobsen, Tim Mandelkow, Niclas C. Blessin, Christina Möller‐Koop, Florian Lutz, Florian Viehweger, Katharina Möller, Guido Sauter, Maximilian Lennartz, Eike Burandt, Patrick Lebok, Sarah Minner, Sarah Bonk, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Christoph Fraune   +26 more
doaj   +1 more source

Clinicopathologic Significance of Survivin Expression in Relation to CD133 Expression in Surgically Resected Stage II or III Colorectal Cancer [PDF]

Journal of Pathology and Translational Medicine, 2017
Background Cancer stem cells have been investigated as new targets for colorectal cancer (CRC) treatment. We recently reported that CD133+ colon cancer cells showed chemoresistance to 5-fluorouracil through increased survivin expression and proposed the ...
Wanlu Li, Mi-Ra Lee, EunHee Choi, Mee-Yon Cho   +3 more
doaj   +1 more source

Expression of survivin and its splice variants survivin-2B and survivin-ΔEx3 in breast cancer [PDF]

British Journal of Cancer, 2004
Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cancer and axillary nodal metastases ...
Ryan, B, O'Donovan, N, Browne, B, O'Shea, C, Crown, J, Hill, A D K, McDermott, E, O'Higgins, N, Duffy, M J   +8 more
openaire   +2 more sources

Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. [PDF]

PLoS ONE, 2012
BACKGROUND:The prognostic significance of survivin for survival of patients with esophageal squamous cell carcinoma (ESCC) remains controversial. Thus, meta-analysis of the literatures was performed in order to demonstrate its expression impact on ESCC ...
Chunguang Li, Zhigang Li, Maoling Zhu, Tiejun Zhao, Ling Chen, Weidan Ji, Hezhong Chen, Changqing Su   +7 more
doaj   +1 more source

Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?

Journal of Experimental & Clinical Cancer Research, 2019
Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field.
Fengzhi Li, Ieman Aljahdali, Xiang Ling
doaj   +1 more source

Function of survivin in trophoblastic cells of the placenta [PDF]

, 2013
Background: Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity worldwide and its pathogenesis is not totally understood.
Reinhard, Joscha, Louwen, Frank, Joscha Reinhard, Cornelia Muschol-Steinmetz (460812), Frank Louwen (460817), Friemel, Alexandra, Alexandra Friemel, Muschol-Steinmetz, Cornelia, Nina-Naomi Kreis, Alexandra Friemel (460813), Juping Yuan (460816), Cornelia Muschol-Steinmetz, Joscha Reinhard (460815), Yuan, Juping, Frank Louwen, Nina-Naomi Kreis (460814), Juping Yuan, Kreis, Nina-Naomi   +17 more
core   +2 more sources