Results 101 to 110 of about 59,431 (239)

Iron oxide nanoparticles and derivatives for biomedical imaging and application in cancer diagnosis and siRNA therapy [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Medarova, Z, Yigit, MV   +2 more
core  

Survivin and tumor

Chinese Journal of Cancer Research, 2003
As a new member of IAP (inhibitors of apoptosis protein) family, survivin has potent anti-apoptotic activities, and involves in the mitosis and angiogenesis. Researches have demonstrated that surviving is a tumor-specific anti-apoptotic factor, expressed in fetal tissues, and common human cancers, while not in normal, terminally differentiated adult ...
Wen-zhe Song, yan Song, Jian-qiao Ye, Dong-tao Qiu   +3 more
openaire   +1 more source

Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

BMC Neuroscience, 2010
Background Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein.
Eisch Amelia, Cremer Harold, Reumers Veerle, Baekelandt Veerle, Moons Michaël, Antonucci Flavia, Cremer Jonathan, DeVriese Astrid, D'Hooge Rudi, Balschun Detlef, Ahmed Tariq, Coremans Vanessa, Lagace Diane, Janssens Tom, Bozzi Yuri, Caleo Matteo, Conway Edward M   +16 more
doaj   +1 more source

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC.

PLoS ONE, 2020
Treating pancreatic ductal adenocarcinoma (PDAC) remains a major hurdle in the field of oncology. Less than half of patients respond to frontline chemotherapy and the pancreatic tumor microenvironment limits the efficacy of immunotherapeutic approaches ...
Matthew Brown, Wanbin Zhang, Deyue Yan, Rajath Kenath, Le Le, He Wang, Daniel Delitto, David Ostrov, Keith Robertson, Chen Liu, Kien Pham   +10 more
doaj   +1 more source

Survivin in Glioblastomas

Archives of Pathology & Laboratory Medicine, 2003
Abstract Context.—Survivin is a novel inhibitor of apoptosis that acts via a pathway independent of bcl-2. Little is known about its distribution in brain tumors or how it correlates with other biomarkers of malignancy, such as telomerase, an enzyme that plays a critical role in cellular immortalization and cancer biology.
B. K. Kleinschmidt-DeMasters, David Heinz, Paul J. McCarthy, Joanna B. Bobak, Kevin O. Lillehei, A. Laurie W. Shroyer, Kenneth R. Shroyer   +6 more
openaire   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Survivin蛋白的原核表达及在肿瘤诊断中的初步应用研究

Zhongguo shiyan zhenduanxue, 2007
目的实现Survivin蛋白在大肠杆菌BL21中的可溶性表达,建立基于Survivin蛋白的Survivin抗体检测方法,为survivin的深入研究及肿瘤的早期诊断奠定基础。方法从食管癌细胞Eca109中提取RNA,经RT-PCR扩增,克隆出Survivin基因;用PCR将Survivin克隆至载体pET32a（+）;用双酶切和DNA测序技术对构建的载体进行鉴定;IPTG诱导Survivin蛋白表达,用镍离子亲和层析纯化,ELISA及Western blot鉴定 ...
郭建巍, 王小平, 马骢, 王珍光, 蒋学兵, 刘敏   +5 more
doaj  

Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]

, 2015
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela, DI LOLLO, ANNA CHIARA, Gambardella, Lucrezia, Malorni, Walter, Straface, Elisabetta, Valesini, Guido   +5 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, Volume 20, Issue 3, Page 727-752, March 2026.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients

Journal of Translational Medicine, 2009
Background We previously reported an HLA-A24-restricted cytotoxic T-cell epitope, Survivin-2B80-88, derived from a splice variant of survivin, survivin-2B.
Yamaguchi Akira, Miyazaki Akihiro, Idenoue Satomi, Hirohashi Yoshihiko, Torigoe Toshihiko, Kobayashi Jun-ichi, Hiratsuka Hiroyoshi, Sato Noriyuki   +7 more
doaj   +1 more source