Results 71 to 80 of about 59,431 (239)

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2009
Background p53AIP1 is a potential mediator of apoptosis depending on p53, which is mutated in many kinds of carcinoma. High survivin expression in non-small cell lung cancer is related with poor prognosis.
Yamamoto Satoshi, Anami Kentaro, Tokuishi Keita, Miyawaki Michiyo, Chujo Masao, Yamashita Shin-ichi, Kawahara Katsunobu   +6 more
doaj   +1 more source

Survivin – The inconvenient IAP [PDF]

Seminars in Cell & Developmental Biology, 2015
Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has consistently defied assumptions, refuted predictions and challenged paradigms. Despite its more than 5500 citations currently in Medline, the biology of survivin has remained fascinatingly complex, its exploitation in human disease, most notably cancer ...
openaire   +2 more sources

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Expression of Survivin and Its Spliced Variants in Bladder Tumors as a Potential Prognostic Marker

Urology Journal, 2009
<p><strong>Introduction: </strong>Survivin, a novel inhibitor of apoptosis, is re-expressed in a vast majority of human cancers and is widely considered as a diagnostic marker of cancers.
Ardalan Ozhand, Mahmoud Parvin, Nazila Nouraee, Seyed Javad Mowla, Seyed Amir Mohsen Ziaee, Nasim Hatefi   +5 more
doaj  

Survivin expression and its clinical significance in pancreatic cancer

BMC Cancer, 2005
Background Survivin, an inhibitor of apoptosis is expressed in several human cancers. Its expression is known to be associated with poor clinical outcome, but not widely studied in pancreatic cancer.
Lee Kyung Shik, Hong Young Seon, Kang Jin-Hyoung, Jung Ji-Han, Lee Hee-Jung, Park Gyeong-sin, Lee Myung Ah, Kim Dong-gu, Kim Seung-Nam   +8 more
doaj   +1 more source

Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis

Scientific Reports, 2021
Sepsis is a dysregulated host response to infection related to devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology.
Marianna Miliaraki, Panagiotis Briassoulis, Stavroula Ilia, Aikaterini Polonifi, Marina Mantzourani, Efrossini Briassouli, Konstantinos Vardas, Serafim Nanas, Aikaterini Pistiki, Maria Theodorakopoulou, Theonymfi Tavladaki, Anna Maria Spanaki, Eumorfia Kondili, Helen Dimitriou, Sotirios Tsiodras, Dimitrios Georgopoulos, Apostolos Armaganidis, George Daikos, George Briassoulis   +18 more
doaj   +1 more source

Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]

, 2010
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Albini, Adriana, Bachmeier, Beatrice E., Blengio, Fabiola, Dell'Eva, Raffaella, Esposito, Alessia, Generoso, Luca, Killian, Peter H., Mirisola, Valentina, Pfeffer, Ulrich, Romeo, Francesco   +9 more
core   +1 more source

Targeting survivin in cancer [PDF]

Cancer Letters, 2013
With almost 4000 citations in Medline in a little over 10 years, survivin has certainly kept scores of investigators busy worldwide. Tangible progress has been made in revealing the multiple functions of survivin, uncovering their wirings as integrated cellular networks, and mapping their exploitation in virtually every human tumor, in vivo ...
openaire   +2 more sources

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source