Results 21 to 30 of about 2,840,578 (328)
T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj +1 more source
Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter +9 more
doaj +1 more source
Antifungal Resistance Analysis of Environmental Isolates of Aspergillus in North India
Triazoles are the major group of antifungals for treating Aspergillus infections. The morbidity and mortality associated with these infections is high and rate of treatment failure is more in patients infected with azole resistant Aspergillus.
Shanu Hoda +4 more
doaj +1 more source
Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk
Background Tick distribution in Sweden has increased in recent years, with the prevalence of ticks predicted to spread towards the northern parts of the country, thus increasing the risk of tick-borne zoonoses in new regions. Tick-borne encephalitis (TBE)
Amélie Wallenhammar +8 more
doaj +1 more source
Local quantum thermal susceptibility [PDF]
Thermodynamics relies on the possibility to describe systems composed of a large number of constituents in terms of few macroscopic variables. Its foundations are rooted into the paradigm of statistical mechanics, where thermal properties originate from ...
De Pasquale, Antonella +3 more
core +2 more sources
Clinical limitations and drug-resistance are the basis of the search for new antifungal therapeutics against biofilm forming pathogen Aspergillus fumigatus.
Shanu Hoda +5 more
doaj +1 more source
Fidelity susceptibility in the two-dimensional transverse field Ising and XXZ models [PDF]
We study the fidelity susceptibility in the two-dimensional(2D) transverse field Ising model and the 2D XXZ model numerically. It is found that in both models, the fidelity susceptibility as a function of the driving parameter diverges at the critical ...
Ho-Man Kwok +4 more
core +1 more source
Minigene Splicing Assays Identify 12 Spliceogenic Variants of BRCA2 Exons 14 and 15
A relevant fraction of BRCA2 variants is associated with splicing alterations and with an increased risk of hereditary breast and ovarian cancer (HBOC). In this work, we have carried out a thorough study of variants from BRCA2 exons 14 and 15 reported at
Eugenia Fraile-Bethencourt +5 more
doaj +1 more source
Genome-wide association studies have identified thousands of loci associated with common diseases and traits. However, a large fraction of heritability remains unexplained.
Anna Díez-Villanueva +9 more
doaj +1 more source
Identification of Eight Spliceogenic Variants in BRCA2 Exon 16 by Minigene Assays
Genetic testing of BRCA1 and BRCA2 identifies a large number of variants of uncertain clinical significance whose functional and clinical interpretations pose a challenge for genetic counseling.
Eugenia Fraile-Bethencourt +5 more
doaj +1 more source

