Results 81 to 90 of about 2,840,578 (328)

Targeting metastatic breast cancer: problems and potential [v1; ref status: indexed, http://f1000r.es/534]

open access: yesF1000Research, 2015
Breast cancer is one of the leading causes of cancer-related mortality of women in the United States. Since the majority of cancer deaths are due to metastases rather than the primary tumor, a better understanding of the biological mechanisms that lead ...
Sarah Deasy   +2 more
doaj   +1 more source

Assessment of the susceptibility to pests and diseases of 36 apple cultivars in four low-input organic orchards in France [PDF]

open access: yes, 2010
One of the keystones of the organic orchard is the cultivar choice as one element of pest and disease control. However, few exhaustive data sets concerning the cultivar susceptibility to pests and diseases are available for growers.
Brun, Laurent   +11 more
core  

Topological Susceptibility from Slabs [PDF]

open access: yes, 2015
In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility chi_t. In principle it seems straightforward to measure chi_t by means of Monte Carlo simulations.
Bietenholz, Wolfgang   +2 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Axial $U(1)$ symmetry at high temperature in 2-flavor lattice QCD [PDF]

open access: yes, 2017
We investigate the axial $U(1)_A$ symmetry breaking above the critical temperature in two-flavor lattice QCD. The ensembles are generated with dynamical M\"obius domain-wall or reweighted overlap fermions.
Aoki, Sinya   +5 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro

open access: yesFrontiers in Pharmacology, 2019
Stress has been proven to modulate an individual’s immune system through the release of pituitary and adrenal hormones such as the catecholamines, growth hormone, and glucocorticoids.
Zhuo Luo   +23 more
doaj   +1 more source

Theory of Orbital Susceptibility on Excitonic Insulator

open access: yes, 2016
We study the temperature dependence of the orbital susceptibility of an excitonic insulator on the basis of a two-band model. It is shown that a drastic change (an anomalous enhancement) in susceptibility as a function of temperature occurs owing to the ...
Matsuura, Hiroyasu, Ogata, Masao
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Brown rot blossom blight of pome and stone fruits: symptom, disease cycle, host resistance, and biological control

open access: yesInternational Journal of Horticultural Science, 2008
In this paper, important features of symptoms, biology and biological disease management are summarised for brown rot blossom blight fungi of pome and stone fruit crops (Monilinia laxa, Monilinia fructicola and Monilinia mali).
I. J. Holb
doaj   +1 more source

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