Results 121 to 130 of about 6,240,497 (308)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Guidance on Evaluation Inception Reports

, 2023
This document provides guidance on how to develop an evaluation Inception Report and its core contents, namely the evaluation purpose, focus, design and ...
CGIAR Independent Evaluation Arrangement
core   +1 more source

Colonic polyps: inheritance, susceptibility, risk evaluation, and diagnostic management

Cancer Management and Research, 2010
Emanuele Neri, Lorenzo Faggioni, Lorenzo Cini, Carlo BartolozziDiagnostic and Interventional Radiology, University of Pisa, Pisa, ItalyAbstract: Colorectal cancer (CRC) is the third-ranked neoplasm in order of incidence and mortality, worldwide, and the ...
Emanuele Neri, Lorenzo Faggioni, Lorenzo Cini, et al   +3 more
doaj  

A study on multiple-model evaluation of landslide susceptibility

Carsologica Sinica
Landslides are one of the most common geological disasters in China, characterized by sudden occurrence and uncertainty. The evaluation of landslide susceptibility is a complex process.
Cheng HUANG, Yunlong DENG, Xiangsheng YAN, Xincheng ZHOU   +3 more
doaj   +1 more source

An Evaluation of World Bank Investment Climate Activities

, 2004
The Investment Climate Study is a evaluation of the Operations Evaluation Department (OED). The OED report reviews the Bank’s investment climate lending and non-lending activities during fiscal years 1993 through
Operations Evaluation Department
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Exploration of slope-type geological hazard susceptibility evaluation based on dynamic correction of SBAS-InSAR technology: A case study of Kang County in Gansu Province

Ecological Informatics
The assessment of geological disaster susceptibility is crucial for early warning, prevention, and mitigation of disasters. Current methods for evaluating geological disasters rely primarily on static factors that cause disasters and historical data at ...
Rongwei Li, Pengwei Wang, Shucheng Tan, Yangbiao Zhou, Lifeng Liu, Chaodong Gou, Yalan Yu   +6 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Evaluation of Landslide Susceptibility in Tekes County, Yili Prefecture Based on the Information Quantity Method

Applied Sciences
In order to scientifically and rationally evaluate the susceptibility to landslide hazards in Tekes County, Yili State. This paper takes Tekes County in Xinjiang as an example, on the basis of a comprehensive analysis of the regional geological ...
Xiaohong Cao, Bin Wu, Yanjun Shang, Weizhong Wang, Tao Xu, Qiaoxue Li, He Meng   +6 more
doaj   +1 more source