Results 131 to 140 of about 6,240,497 (308)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Evaluation of Rainfall-Induced Accumulation Landslide Susceptibility Based on Remote Sensing Interpretation

Remote Sensing
Landslide susceptibility evaluation is an indispensable part of disaster prevention and mitigation work. Selecting effective evaluation methods and models for landslide susceptibility assessment is of significant importance.
Zhen Wu, Runqing Ye, Jue Huang, Xiaolin Fu, Yao Chen   +4 more
doaj   +1 more source

Evaluation of Scaling Efforts in CGIAR: Technical Note

CGIAR has maintained a long-standing commitment to scaling the public benefits of its innovations and has recently reinforced this priority. This renewed emphasis has generated an increasing need for the systematic evaluation of scaling efforts.
CGIAR Independent Advisory and Evaluation Service
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

New method for landslide susceptibility evaluation in alpine valley regions that considers the suitability of InSAR monitoring and introduces deformation rate grading

Geo-spatial Information Science
Incorporating Interferometric Synthetic Aperture Radar (InSAR) data sources into the landslide susceptibility evaluation process has yielded favorable outcomes in some studies.
Dingyi Zhou, Zhifang Zhao, Wenfei Xi, Xin Zhao, Jiangqin Chao   +4 more
doaj   +1 more source

Improved recovery of Mycobacterium tuberculosis from children using the microscopic observation drug susceptibility method.

, 2006
OBJECTIVE: The diagnosis of pulmonary tuberculosis presents challenges in children, because symptoms are nonspecific, sputa are not accessible, and Mycobacterium tuberculosis cultures and smears often are negative.
Luz Caviedes, Oberhelman, Richard A, Gilman, Robert H, Giselle Soto-Castellares, Carlton Evans, Castillo, Maria E, Robert H. Gilman, Moore, David AJ, David A.J. Moore, Maria E. Castillo, Patricia Kissinger, Richard A. Oberhelman, Caviedes, Luz, Evans, Carlton, Soto-Castellares, Giselle, Kissinger, Patricia   +15 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Dynamic evaluation of landslide susceptibility in Heifangtai, Gansu based on time-series InSAR and multi-temporal cataloguing

Zhongguo dizhi zaihai yu fangzhi xuebao
Landslide disasters occur frequently in the mountainous regions of western China, and accurate classification of landslide hazard risk levels is crucial for effective geohazard mitigation.
Qing LING, Jiebo QU, Xinghai DANG, Qi GUO, Junguang REN, Yuming WEI   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Working together to strengthen skills : IDRC's strategic evaluation of capacity development, phase 3; developing the framework

, 2007
French version available in IDRC Digital Library: Renforcement concerté des capacités : phase 3 de l'évaluation stratégique des activités de renforcement des capacités du CRDI; élaboration du cadre d'évaluationThis “Evaluation Highlights ...
IDRC. Evaluation Unit
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