Results 111 to 120 of about 6,323,337 (377)

An xa5 Resistance Gene-Breaking Indian Strain of the Rice Bacterial Blight Pathogen Xanthomonas oryzae pv. oryzae Is Nearly Identical to a Thai Strain

Frontiers in Microbiology, 2020
The rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) constrains production in major rice growing countries of Asia. Xoo injects transcription activator-like effectors (TALEs) that bind to and activate host “susceptibility” (S) genes ...
Sara C. D. Carpenter, Prashant Mishra, Chandrika Ghoshal, Prasanta K. Dash, Li Wang, Samriti Midha, Gouri S. Laha, Jagjeet S. Lore, Wichai Kositratana, Nagendra K. Singh, Kuldeep Singh, Prabhu B. Patil, Ricardo Oliva, Sujin Patarapuwadol, Adam J. Bogdanove, Rhitu Rai   +15 more
doaj   +1 more source

A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes [PDF]

, 2008
A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)^1^.
Duš, Iveta Waczulí, Já, Jozef Hatok, Monika Sivoň, Peter Rač, Tatiana Matá   +6 more
core   +1 more source

C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]

, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper, AB Singleton, AD Gitler, B Rogina, C Hertzman, CD Link, E Berezikov, E Cuppen, EA Nollen, Ellen A. A. Nollen, GM Halliday, HA Tissenbaum, HG van, HH Liou, HM Beere, JF Morley, Karen L. Thijssen, L Chen, M Kaeberlein, M Kaeberlein, M Nishimura, M Viswanathan, MC Chartier-Harlin, MG Spillantini, MG Spillantini, MH Polymeropoulos, NB Cole, PK Auluck, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, S Kim, S Miksys, S Roy, S Willingham, Stuart K. Kim, T Kai, TF Outeiro, Tjakko J. van Ham   +38 more
core   +8 more sources

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Nature Communications, 2015
Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci.
K. Lawrenson, Qiyuan Li, S. Kar, Ji-Heui Seo, J. Tyrer, T. Spindler, Janet M. Lee, Yibu Chen, Alison M. Karst, R. Drapkin, K. Aben, H. Anton-Culver, N. Antonenkova, David Penelope M. Anna Bowtell Webb deFazio, D. Bowtell, P. Webb, A. Defazio, Helen Baker, E. Bandera, Yukie T. Bean, M. Beckmann, A. Berchuck, Maria Bisogna, L. Bjørge, N. Bogdanova, L. Brinton, A. Brooks-Wilson, F. Bruinsma, R. Butzow, I. Campbell, K. Carty, J. Chang-Claude, G. Chenevix-Trench, Ann Chen, Zhihua Chen, L. Cook, D. Cramer, J. Cunningham, C. Cybulski, A. Dansonka-Mieszkowska, J. Dennis, E. Dicks, J. Doherty, T. Dörk, A. du Bois, M. Dürst, D. Eccles, D. Easton, R. Edwards, U. Eilber, A. Ekici, P. Fasching, B. Fridley, Yu-Tang Gao, A. Gentry-Maharaj, G. Giles, R. Glasspool, E. Goode, M. Goodman, Jacek Grownwald, P. Harrington, P. Harter, H. Hasmad, A. Hein, F. Heitz, M. Hildebrandt, P. Hillemanns, E. Høgdall, C. Høgdall, S. Hosono, E. Iversen, A. Jakubowska, P. James, A. Jensen, B. Ji, B. Karlan, S. Kruger Kjaer, L. Kelemen, Melissa Kellar, J. Kelley, L. Kiemeney, C. Krakstad, J. Kupryjańczyk, D. Lambrechts, S. Lambrechts, N. Le, Alice W. Lee, S. Lele, A. Leminen, J. Lester, D. Levine, Dong Liang, J. Lissowska, K. Lu, J. Lubiński, L. Lundvall, L. Massuger, K. Matsuo, V. McGuire, J. McLaughlin, H. Nevanlinna, I. McNeish, U. Menon, F. Modugno, K. Moysich, S. Narod, L. Nedergaard, R. Ness, M. Azmi, K. Odunsi, S. Olson, I. Orlow, S. Orsulic, R. P. Weber, C. Pearce, T. Pejovic, Liisa M. Pelttari, Jennifer Permuth‐Wey, C. Phelan, M. Pike, E. Poole, S. Ramus, H. Risch, B. Rosen, M. Rossing, J. Rothstein, A. Rudolph, I. Runnebaum, I. Rzepecka, H. Salvesen, J. Schildkraut, I. Schwaab, T. Sellers, X. Shu, Yurii B. Shvetsov, N. Siddiqui, W. Sieh, Honglin Song, M. Southey, Lara E. Sucheston, I. L. Tangen, S. Teo, K. Terry, P. Thompson, A. Timorek, Ya‐Yu Tsai, S. Tworoger, A. van Altena, E. Van Nieuwenhuysen, I. Vergote, R. Vierkant, S. Wang-gohrke, C. Walsh, N. Wentzensen, A. Whittemore, K. Wicklund, L. Wilkens, Y. Woo, Xifeng Wu, A. Wu, Hannah P. Yang, W. Zheng, A. Ziogas, A. Monteiro, P. Pharoah, S. Gayther, M. Freedman   +166 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to rheumatoid arthritis [PDF]

, 2009
Objective: Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1β and tumour
Binks, M.H., Dickson, M.C., Marinou, L., Montgomery, D.S., Walters, K., Wilson, A.G.   +5 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcriptional profiling of Impatiens walleriana genes through different stages of downy mildew infection reveals novel genes involved in disease susceptibility

Ornamental Plant Research
Impatiens downy mildew is a highly destructive disease of Impatiens walleriana, an economically important bedding ornamental crop. This disease is caused by a recently emerged pathogen Plasmopara obducens.
Stephanie Suarez, Zunaira Afzal Naveed, Gul Shad Ali   +2 more
doaj   +1 more source

Disease susceptibility genes for autism

Annals of Medicine, 2003
Autism is a complex neurodevelopmental disorder characterized by impairment in social interaction accompanied by a delay or lack of language, restricted interests, stereotyped behavior, and repetitive movement. Genetic predisposition to autism is evident from family and twin studies, and heritability in idiopathic autism is estimated at over 90 ...
Irina N, Bespalova, Joseph D, Buxbaum
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source