Results 201 to 210 of about 930,320 (303)

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing. [PDF]

Cancers (Basel)
Song R, Mikaeel RR, He Z, Horsnell M, Uylaki W, Meng W, Poplawski NK, Wollnik B, Li Y, Feng J, Scott HS, Shen Y, Wang C, Yin R, Ding Y, Llor X, Chung WK, Smith E, Price TJ, Young JP, Fan X.   +20 more
europepmc   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes. [PDF]

NPJ Breast Cancer
Collister JA, Smith-Byrne K, Atkins J, Reeves G, Hunter DJ.   +4 more
europepmc   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Winning by Losing: Exploiting Modified Plant Susceptibility Genes to Counteract Necrotrophic Fungal Pathogens. [PDF]

Plant Biotechnol J
You Y, Ramírez Gaona M, Bai Y, van Kan JAL, Wolters AA.   +4 more
europepmc   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Anorexia susceptibility gene variant [PDF]

Genome Biology, 2001
openaire   +1 more source

A splicing-based multitissue association study of joint transcriptomes identified susceptibility genes for osteoarthritis. [PDF]

Front Immunol
Zhang L, Zhao F, Zhang H, Niu X, Li Y, Zhao C, Ding J, Liu C.   +7 more
europepmc   +1 more source