Results 31 to 40 of about 71,334 (266)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Vibration control of a large slewing crane by combining a plant model considering boom deflection with an inverse dynamics based on a rigid boom model

ROBOMECH Journal
Slewing cranes are useful for the handling work of heavy objects, such as in construction works. However, the load sway of the crane is a major problem, because it reduces safety and workability.
Soichiro Ide, Ayato Kanada, Yasutaka Nakashima, Kazuma Mizuki, Motoji Yamamoto   +4 more
doaj   +1 more source

A novel framework for turbidity source apportionment of the urban lakeside river network

Ecological Indicators, 2023
Turbidity source apportionment is essential but complex for precise environmental rehabilitation of worldwide urban lakeside river networks impaired by turbidity.
Renhua Yan, Jing Yao, Feng Tian, Junfeng Gao   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

ASSESSING SUSPENDED SEDIMENT YIELD IN THE SAF SAF GAUGED CATCHMENT, NORTHEASTERN ALGERIA [PDF]

Malaysian Journal of Geosciences, 2019
Many studies on sediment transport have been carried out on Algerian rivers but few studies have been undertaken in catchments of the Northeast of Algeria. The scarcity or discontinuity on sediment transport measurements reduces knowledge about soil loss.
K. Khanchoul, Z.A. Boukhrissa
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dynamics and deposits generated by the Kos Plateau Tuff eruption: Controls of basal particle loss on pyroclastic flow transport

Geochemistry, Geophysics, Geosystems, 2007
The explosive eruption of voluminous silicic magmas often produces widespread and massive deposits formed from pyroclastic density currents. While these punctuated events dramatically alter the landscape and have potential climate‐altering impact, our ...
Josef Dufek, George W. Bergantz
doaj   +1 more source

Seasonal and Spatial Characteristics of Suspended Sediment Load and their Controlling Factors in the Upper Indus River Basin, Pakistan

Pakistan Journal of Analytical & Environmental Chemistry, 2023
Understanding the seasonal and spatial characteristics of suspended sediment load is extremely important for efficient water resource management. The characteristics of suspended sediment load reflect the soil erosion, transport and deposition. The upper
Muhammad Dodo Jagirani, XiaonanShi, Fan Zhang, Shahram Khalighi-Sigaroodi, Chen Zeng, Xiong Xiao, Li Wang, Faizan ur Rehman Qaiser, Guanxing Wang   +8 more
doaj   +1 more source