Results 31 to 40 of about 427 (202)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Deposición electroforética de una porcelana dental sobre acero inoxidable austenítico 304
Boletín de la Sociedad Española de Cerámica y Vidrio, 2003 An alternative technique for the production of dental restorations with porcelain, is the electrophoretic deposition (EPD). In this work, deposits of dental porcelain on stainless steel were obtained by EPD using water, ethanol and isopropanol as ...
Vargas, G. +4 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Revista Colombiana de Biotecnología, 2009 La obtención de un sistema de regeneración eficiente por medio de la embriogénesis somática en las Musaceas, es hoy una gran herramienta ante los enormes problemas que presenta este género con el ataque de enfermedades como la sigatoka negra. El objetivo
Luis A. Barranco Olivera +5 more
doaj +2 more sources
Boletín de la Sociedad Española de Cerámica y Vidrio, 1999 In this paper are presented the results obtained by the characterisation and the study of the rheological behavior of concentrated frits suspensions used in the preparation of ceramic glazes for single firing porous tiles.
Andreola, F., Pozzi, P., Romagnoli, M.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
EFECTO DE LA VISCOSIDAD DE SUSPENSIONES SOBRE EL FUNCIONAMIENTO DE HIDROCICLONES DE DIÁMETRO PEQUEÑO
Dyna, 2009 Se presentan los resultados de un estudio experimental de clasificación de minerales en hidrociclones de diámetro pequeño, operando con suspensiones minerales de minerales arcillosos.
M. OSWALDO BUSTAMANTE +2 more
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