Results 51 to 60 of about 7,608 (271)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Desarrollo de materiales compuestos de titanio obtenidos mediante conformado de suspensiones [PDF]
, 2017 De forma convencional, la cerámica se procesa utilizando tecnologías de polvos, bien sea en seco o en húmedo. Son los métodos de procesamiento a partir de suspensiones (vía húmeda) los que últimamente han permitido fabricar piezas con formas complejas, e
Cánovas Espinosa, María
core +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
EFECTO DE LA VISCOSIDAD DE SUSPENSIONES SOBRE EL FUNCIONAMIENTO DE HIDROCICLONES DE DIÁMETRO PEQUEÑO
Dyna, 2009 Se presentan los resultados de un estudio experimental de clasificación de minerales en hidrociclones de diámetro pequeño, operando con suspensiones minerales de minerales arcillosos.
M. OSWALDO BUSTAMANTE +2 more
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Establecimiento de un cultivo de celulas en suspensión de Eucalyptus cinérea
Revista Colombiana de Biotecnología, 2002 Se desarrolla un protocolo para la obtención y establecimiento de suspensiones celulares de E. cinerea. La concentración de las hormonas 2,4 D Y BAP tienen un efecto significativo en la formación de callos friables de E. cinerea, obteniendo una respuesta
Fernando Orozco Sáncnez +2 more
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Dominguezia, 2023 Nuestro objetivo fue comparar los niveles de expresión de la proteína E2 del virus de la diarrea viral bovina (VDVB) expresada mediante transformación estable o transitoria en plantas de tabaco.
Melina Laguia Becher +4 more
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