Results 131 to 140 of about 5,479,695 (430)
Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding
FEBS Open Bio, EarlyView.The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla +4 more
wiley +1 more source
A Previously not Described Injury to the Wrist Sustained During Boxing [PDF]
, 1932 Erik Hellgren
openalex +1 more source
Sustainability Transitions Research: Transforming Science and Practice for Societal Change
, 2017 The article describes the field of sustainability transitions research, which emerged in the past two decades in the context of a growing scientific and public interest in large-scale societal transformation toward sustainability.
D. Loorbach +2 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
The 4.2 ka event is not remarkable in the context of Holocene climate variability
Nature CommunicationsThe “4.2 ka event” is a commonly described abrupt climate excursion that occurred about 4200 years ago. However, the extent to which this event is coherent across regional and larger scales is unclear.
Nicholas P. McKay +11 more
doaj +1 more source
Sustainability‐Oriented Innovation: A Systematic Review
, 2016 This paper is intended as a contribution to the ongoing conceptual development of sustainability‐oriented innovation (SOI) and provides initial guidance on becoming and being sustainable.
R. Adams +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Clearing the Path for Software Sustainability [PDF]
arXivThe advancement of software sustainability encounters notable challenges, underscoring the necessity for understanding these challenges to facilitate significant progress and pave the way for effective solutions to advance software sustainability.
arxiv