Results 131 to 140 of about 4,514,983 (297)

Risk Assessment and Sustainable Development: Towards a Concept of Sustainable Risk [PDF]

, 1997
Dr. Mehta examines two dominant approaches for managing health and environmental risks and suggests that they would better serve if ...
Mehta, Michael D.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Enhancing Supplier Selection for Sustainable Raw Materials: A Comprehensive Analysis Using Analytical Network Process (ANP) and TOPSIS Methods

Logistics
Background: This research endeavors to enhance supplier selection processes by combining the Analytic Network Process (ANP) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) methodologies, with a specific focus on ...
Ilyas Masudin, Isna Zahrotul Habibah, Rahmad Wisnu Wardana, Dian Palupi Restuputri, S. Sarifah Radiah Shariff   +4 more
doaj   +1 more source

Smart & sustainable cities [PDF]

, 2013
The University of Strathclyde is creating a new Institute for Future Cities that aims to improve the quality of human life across the world through innovative research that enables cities to be understood in new ways, and innovative approaches to be ...
Bellingham, Richard, Purshouse, Nicholas
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Leveraging digital technology to achieve sustainable interactive work environments

Journal of Architecture, Art & Humanistic Science
The importance of work environments stems from their central role in inclusive and sustainable economic growth, which is important in advancing the process of progress and achieving the eighth goal of sustainable development, as well as the importance of
Dr. Amara Elsayed Abd Alazeem Elsayed
doaj   +1 more source

A grassroots sustainable energy niche? Reflections on community energy case studies [PDF]

, 2013
System changing innovations for sustainability transitions are proposed to emerge in radical innovative niches. ‘Strategic Niche Management’ theory predicts that niche level actors and networks will aggregate learning from local projects, distilling and ...
Hargreaves, Tom, Hielscher, Sabine, Martiskainen, Mari, Seyfang, Gill, Smith, Adrian   +4 more
core   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source