Results 91 to 100 of about 16,651,905 (345)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Household smoke exposure risk and acute respiratory infection among children under five years in sub-Saharan Africa: evidence from the demographic and health surveys

BMC Public Health
Background Exposure to smoke from unclean fuels increases children’s risk of acute respiratory infection (ARI). Although studies have extensively examined the association between the type of cooking fuel used and ARI in sub-Saharan Africa (SSA), few have
Michael Larbi Odame, Rexford Kweku Asiama, Margaret Appiah, Grace Frempong Afrifa-Anane, Frank Kyei-Arthur   +4 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Dairy farmers’ levels of awareness of antibiotic use in livestock farming in Pakistan

Humanities & Social Sciences Communications
Antimicrobial resistance due to the irrational and non-sustainable use of antimicrobials poses a serious threat to animal health, human health and urban food security.
Muhammad Farhan, Namra Awan, Amina Kanwal, Faiza Sharif, Muhammad Umar Hayyat, Laila Shahzad, Gul Zareen Ghafoor   +6 more
doaj   +1 more source

Profit as a predictor variable for environmental sustainability practices (ESPs) of manufacturing companies for achieving green manufacturing in contemporary Ghana

Cogent Economics & Finance
The complex relationship between profit margins and environmental sustainability practices (ESPs) in Ghana’s manufacturing industry is examined in this study. Utilizing information gathered from six manufacturing firms, the study uses regression analysis
Kwame B. Bour, Kwaku Adu, Anthony Amoah, Braimah Kassum, Collins Gameli Hodoli, Patience A. K. Awua-Boateng   +5 more
doaj   +1 more source

Conservation and sustainable development in a VUCA world: the need for a systemic and ecosystem‐based approach

Ecosystem Health and Sustainability, 2017
Targeting the maintenance of functional ecosystems that provide the significant basis for human well‐being is an integral part of an ecosystem‐based sustainable development.
Axel Schick, Peter R. Hobson, Pierre L. Ibisch   +2 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Welfare Impacts of Afghan Trade on the Pakistani Provinces of Balochistan and Khyber Pakhtunkhwa

Stability : International Journal of Security and Development, 2015
Amidst all the concerns of uncertainty over the future of Afghanistan, recent developments have given hope to the world, specifically south and central Asia.
Saad Shabbir, Vaqar Ahmed
doaj   +1 more source

Conceptual Analysis of Sustainable Development and Sustainable Development.

Investigacion e Innovación en Ingenierias, 2014
El presente artículo es una reflexión  acerca de los conceptos desarrollo sostenible y desarrollo sustentable, términos que generan discusión en su acepción en el ámbito de la gestión ambiental. Para lo cual se desarrolló una revisión de la bibliografía relacionada con el objeto de esta reflexión.
Ludys López Polo, Efraín Javier De La Hoz Granadillo   +1 more
openaire   +3 more sources