Results 51 to 60 of about 552,492 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Performance of horizontal flow constructed wetland for secondary treatment of domestic wastewater in a remote tribal area of Central India

Sustainable Environment Research, 2021
The purification of the primary treated domestic sewage was performed in the present study through the horizontal sub-surface flow constructed wetland (CW) of 10 × 3.5 m dimension.
Reetika Shukla, Deepak Gupta, Gurudatta Singh, Virendra Kumar Mishra   +3 more
doaj   +1 more source

Economic Growth And Sustainable Development: Sustainability or Sustainable Development?

Refuge: Canada's Journal on Refugees, 1996
Depuis les trois dernieres decades, le debat sur le developpement durable s'est caracterise par une etroite politique de developpement et de l'environnement laissant une large marge aux interpretations. Ces interpretations ne correspondent pas souvent a celles de ceux qui utilisent les forces du marche ainsi que les multinationales pour mieux ...
openaire   +3 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Disaster Risk Reduction Including Climate Change Adaptation Over South Asia: Challenges and Ways Forward

International Journal of Disaster Risk Science, 2018
South Asia is vulnerable to a variety of hydrometeorological hazards, which are often cross-boundary in nature. Climate change is expected to influence many of these hazards.
Rajesh K. Mall, Ravindra K. Srivastava, Tirthankar Banerjee, Om Prakash Mishra, Diva Bhatt, Geetika Sonkar   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Gender disparities in agricultural land access and cashew farming participation in Kintampo South District, Ghana

Journal of Agriculture and Rural Development in the Tropics and Subtropics
This study examines gender disparities in access to agricultural land and participation, using a sample of 200 cashew farmers in the Kintampo South District of Ghana and descriptive statistical analysis.
Daniella Delali Sedegah
doaj   +1 more source