Results 71 to 80 of about 709,395 (249)

Effect of discontinuous fair-share emissions allocations immediately based on equity

Nature Communications
National emissions targets are collectively insufficient to align with the Paris Agreement. The fair-share literature assesses whether these targets are fair and ambitious in comparison to emissions trajectories based on equity principles. Such emissions
Yann Robiou du Pont, Mark Dekker, Detlef van Vuuren, Michiel Schaeffer   +3 more
doaj   +1 more source

Energy security assessment in rural communities in Brazil: A contribution to public policies

Energy Nexus
Energy security refers to the continuous and reliable access to energy sources at an affordable cost. In rural areas, particularly in Brazil's semi-arid regions, this security is essential for the survival and development of communities.
Wesly Jean, Marcel Bursztyn, Elton S. Oliveira, Júlia Lopes, Guadalupe Sátiro, Saulo Rodrigues Filho, Diego Lindoso, Juliana Dalboni Rocha, Nelson Bernal, Daniela Nogueira   +9 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Household smoke exposure risk and acute respiratory infection among children under five years in sub-Saharan Africa: evidence from the demographic and health surveys

BMC Public Health
Background Exposure to smoke from unclean fuels increases children’s risk of acute respiratory infection (ARI). Although studies have extensively examined the association between the type of cooking fuel used and ARI in sub-Saharan Africa (SSA), few have
Michael Larbi Odame, Rexford Kweku Asiama, Margaret Appiah, Grace Frempong Afrifa-Anane, Frank Kyei-Arthur   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dairy farmers’ levels of awareness of antibiotic use in livestock farming in Pakistan

Humanities & Social Sciences Communications
Antimicrobial resistance due to the irrational and non-sustainable use of antimicrobials poses a serious threat to animal health, human health and urban food security.
Muhammad Farhan, Namra Awan, Amina Kanwal, Faiza Sharif, Muhammad Umar Hayyat, Laila Shahzad, Gul Zareen Ghafoor   +6 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Towards a Visual Typology of Sustainability and Sustainable Development [PDF]

, 2020
Jonathan R. Barton, Felipe Gutiérrez-Antinopai   +1 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source