Results 81 to 90 of about 16,651,905 (345)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Growth, Development and Sustainability [PDF]

Revista Română de Statistică, 2013
Describing the relationship of interdependence through the materials balance, will be argued how the economy is a subset of the environment and the environment the natural limit to any economic initiative, or the limits imposed by the laws of thermodynamics.
Irina-Virginia DRAGULANESCU, Natalia DRAGULANESCU   +1 more
openaire   +2 more sources

Staircase To Sustainable Development [PDF]

Foundations of Management, 2015
Abstract The aim of this article to provide a theoretical framework on the concepts of Sustainable Development and the process that companies need to follow in order to ensure the future sustainability of business operations. Various secondary sources and previous literature was reviewed to clearly identify why companies are finding it ...
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Life Cycle Assessment of Valorizing Waste Polyethylene and Coconut Shells Into Activated Carbon Polymer Flakes

International Journal of Chemical Engineering
Polyethylene (PE) accounts for approximately 40% of total global plastic production, yet PE waste remains an underutilized feedstock. Meanwhile, activated carbon (AC) derived primarily from coconut shells (CS), the most popular source, is usually ...
Junaid Saleem, Moghal Zubair Khalid Baig, Furqan Tahir, Gordon McKay   +3 more
doaj   +1 more source

Energy security assessment in rural communities in Brazil: A contribution to public policies

Energy Nexus
Energy security refers to the continuous and reliable access to energy sources at an affordable cost. In rural areas, particularly in Brazil's semi-arid regions, this security is essential for the survival and development of communities.
Wesly Jean, Marcel Bursztyn, Elton S. Oliveira, Júlia Lopes, Guadalupe Sátiro, Saulo Rodrigues Filho, Diego Lindoso, Juliana Dalboni Rocha, Nelson Bernal, Daniela Nogueira   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effect of discontinuous fair-share emissions allocations immediately based on equity

Nature Communications
National emissions targets are collectively insufficient to align with the Paris Agreement. The fair-share literature assesses whether these targets are fair and ambitious in comparison to emissions trajectories based on equity principles. Such emissions
Yann Robiou du Pont, Mark Dekker, Detlef van Vuuren, Michiel Schaeffer   +3 more
doaj   +1 more source

Sustainable development: Meaning, history, principles, pillars, and implications for human action: Literature review

Cogent Social Sciences, 2019
Sustainable development (SD) has become a popular catchphrase in contemporary development discourse. However, in spite of its pervasiveness and the massive popularity it has garnered over the years, the concept still seems unclear as many people continue
Justice Mensah
semanticscholar   +1 more source