Results 61 to 70 of about 624,117 (335)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Towards pre-emptive resilience in military supply chains: A compromise decision support model-based approach

Production and Manufacturing Research: An Open Access Journal, 2023
The complex and dynamic nature of military supply chains (MSC) requires constant vigilance to sense potential vulnerabilities. Several studies have employed decision support models for the optimization of their operations.
Shehu Sani Mohammed, Dirk Schaefer, Jelena Milisavljevic-Syed   +2 more
doaj   +1 more source

Additive manufacturing – a sustainable manufacturing route [PDF]

MATEC Web of Conferences, 2017
Additive Manufacturing (AM) technologies allow developing and manufacturing very complex shaped parts and functional products with a high level of customization, being a great alternative to Traditional Manufacturing (TM) methods like injection molding, die-casting or machining.
Frăţilă, Domniţa, Rotaru, Horaţiu
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Future of business models in manufacturing [PDF]

, 2017
In order to achieve systematic change in pursuit of sustainable manufacturing, both a strategic long-term perspective employing methods from future studies and a concrete implementation of the knowledge gained in sustainable business models are necessary.
Barquet, Ana-Paula, Kohl, Holger, Seidel, Johannes, Seliger, Günther   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Circular economy strategy based on digital technologies and the S4 framework: a case study on smartphones

International Journal of Sustainable Engineering
Smartphones are indispensable tools for daily tasks; nevertheless, their short lifespan of about two years contributes to a disproportionate increase in environmental waste.
Javier Maldonado-Romo, Juana Isabel Méndez, Mario Rojas, Luis Montesinos, Pedro Ponce, Arturo Molina   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lack of verified Inclusive Technology for Workers with disabilities in industry 4.0: a systematic review

International Journal of Sustainable Engineering
Technologies from Industry 4.0 enhance human skills and capabilities in production. These advanced manufacturing and digital technologies unlock opportunities to integrate individuals with unique abilities into industrial environments, helping to attain ...
Mario Rojas, David C. Balderas, Javier Maldonado, Pedro Ponce, Diego Lopez-Bernal, Arturo Molina   +5 more
doaj   +1 more source

An Augmented Reality Based Human-Robot Interaction Interface Using Kalman Filter Sensor Fusion

Sensors, 2019
In this paper, the application of Augmented Reality (AR) for the control and adjustment of robots has been developed, with the aim of making interaction and adjustment of robots easier and more accurate from a remote location.
Chunxu Li, Ashraf Fahmy, Johann Sienz
doaj   +1 more source