Results 81 to 90 of about 31,796 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Polysaccharide-Based Composite Films: Promising Biodegradable Food Packaging Materials

Foods
With growing concerns about environmental protection and sustainable development, the development of new biodegradable food packaging materials has become a significant focus for the future of food packaging. Polysaccharides, such as cellulose, chitosan,
Shengzi Li, Yu Ren, Yujie Hou, Qiping Zhan, Peng Jin, Yonghua Zheng, Zhengguo Wu   +6 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Bibliometric insights into fruit waste valorization for pectin- based sustainable packaging within the circular economy paradigm

Frontiers in Food Science and Technology
The fruit waste and food processing residues are rich in pectin that can be valorized into pectin-based packaging materials aligned with sustainable for circular economy standards.
Rakshana R, Aanchal Mittal, Arkajyoti Dutta   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Recent progress in protein-based food packaging films

Collagen and Leather
With the increase in global plastic pollution and the growing need for sustainable development, the food packaging industry is experiencing an unprecedented paradigm shift.
Jiaqi Lu, Qunna Xu, Jianzhong Ma, Xiaoyu Xu, Yuan Zhao, Yao Pu, Yanting Deng, Kai Yan, Yan Zong, Qianqian Fan   +9 more
doaj   +1 more source

Measurement and Analysis of Last-Mile Parcel Delivery Truck Vibration Levels in Korea

Applied Sciences
South Korea has one of the largest e-commerce markets in the world. The last-mile delivery segment of e-commerce often causes critical damage to products in protective packages.
Saewhan Kim, Laszlo Horvath, Soohyung Lee, Sangwook Lee   +3 more
doaj   +1 more source

Packaging, logistics and sustainability. Exploring innovative solutions for eco-sustainable packaging

, 2023
Framing of the research: The sustainability challenges posed by packaging value chains require urgent actions inside the international and national sustainable product policy framework and industrial strategy. Purpose of the paper: The paper aims at exploring innovative solutions for eco-sustainable packaging considering the implications on logistics ...
openaire   +1 more source