Results 131 to 140 of about 4,253,121 (312)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cephalopod proteins for bioinspired and sustainable biomaterials design
Materials Today BioNature offers a boundless source of inspiration for designing bio-inspired technologies and advanced materials. Cephalopods, including octopuses, squids, and cuttlefish, exhibit remarkable biological adaptations, such as dynamic camouflage for predator evasion and communication, as well as robust prey-capturing tools, including beaks and sucker-ring ...
Lychko, Iana +6 more
openaire +4 more sources
Double dividend : promoting good nutrition and sustainable consumption through healthy school meals [PDF]
, 2012 This report, produced by the Sustainable Consumption Roundtable tackles the issues surrounding promoting good nutrition and sustainable consumption through healthy school meals.Publisher ...
Soil Association +6 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Vision for sustainable regeneration, environment & poverty : the missing link [PDF]
, 2012 This paper sets out our vision for sustainable regeneration, based on a review of existing literature, policy developments and initiatives.Publisher ...
Sustainable Development Commission
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Comments back from the Sustainable Communities Summit Workshop : creating communities with low environmental impact [PDF]
, 2012 Based on 'Report back from Sustainable Communities Summit Workshop : creating communities with a low environmental impact'.Publisher ...
Sustainable Development Commission
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
SDC submission to the DTI energy review : meeting the challenge : energy policy for the 21st century [PDF]
, 2012 Part of a series of documents submitted by the Sustainable Development Commission to inform 'The energy challenge : energy review report 2006'.Publisher ...
Sustainable Development Commission
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source