Results 111 to 120 of about 4,253,121 (312)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Comprehensive area assessment consultation [PDF]
, 2012 The proposals for the new comprehensive area assessment are a very positive step forward for sustainable development compared to previous local performance assessment frameworks, but will need further strengthening if they are to help support the ...
Sustainable Development Commission
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Sustainability and UK food policy 2000-2011 [PDF]
, 2012 A report on food, farming, sustainable consumption and production.Publisher ...
Sustainable Development Commission
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Sustainable communities : qualitative householder research findings from South Cambridgeshire and Barking and Dagenham [PDF]
, 2012 This report is part of the evidence base for 'In-depth review of sustainable communities policy'.This qualitative householder research was carried out to complement the Area-Based Assessments undertaken on behalf of the Sustainable Development Commission.
Sustainable Development Commission
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Location decision factors in food processing and how they can inform a just protein transition
Frontiers in Sustainable Food SystemsProducers of alternative proteins must carefully consider facility location if they are to achieve commercial success and drive positive impact for environment and society.
Henry Bambrick +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Alternative proteins; A path to sustainable diets and environment
Current Research in Food ScienceWith a growing global population and the resulting pressure on natural resources, the supply of high-value protein has become increasingly limited. The rise of environmental and ethical concerns has led to the emergence of meat analogues as a credible alternative to traditional animal-derived meat.
Shima Jafarzadeh +7 more
openaire +3 more sources
National infrastructure : embedding sustainable development in decision making [PDF]
, 2012 By taking a sustainable development approach, local authorities and their partners can play a leading role in delivering integrated environmental, social and economic improvements at the local level.Publisher ...
Sustainable Development Commission
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